Updated:March, 2026

10 Best Nexgard Combo For Cats of 2026

Best Choice

9.9

Outstanding

Nexgard

NexGard® Combo (esafoxolaner, eprinomectin, and praziquantel Topical Solution) Flea and Tick Protection Plus Heartworm Disease Preventive for Cats, 5.6-16.5 lbs. (Yellow Box) 6 Doses (6 Month Supply)

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Why We Love It

Year-round protection from harmful parasites when applied monthly
Convenient one-and-done monthly dosing
First and only feline broad spectrum parasite protection that treats tapeworms.
Protects against adult fleas before they can lay eggs while protecting against black-legged ticks and lone star ticks
Effectively prevents heartworm disease while treating and controlling hookworms, roundworms, and tapeworms

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Why We Love It

Year-round protection from harmful parasites when applied monthly
Convenient one-and-done monthly dosing
First and only feline broad spectrum parasite protection that treats tapeworms.
Protects against adult fleas before they can lay eggs while protecting against black-legged ticks and lone star ticks
Effectively prevents heartworm disease while treating and controlling hookworms, roundworms, and tapeworms

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9.5

Excellent

Nexgard

NexGard® Combo (esafoxolaner, eprinomectin, and praziquantel Topical Solution) Flea and Tick Protection Plus Heartworm Disease Preventive for Cats, 5.6-16.5 lbs. (Yellow Box) 3 Doses (3 Month Supply)

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Main Highlights

Year-round protection from harmful parasites when applied monthly
Convenient one-and-done monthly dosing
First and only feline broad spectrum parasite protection that treats tapeworms.
Protects against adult fleas before they can lay eggs while protecting against black-legged ticks and lone star ticks
Effectively prevents heartworm disease while treating and controlling hookworms, roundworms, and tapeworms

Check Price

Main Highlights

Year-round protection from harmful parasites when applied monthly
Convenient one-and-done monthly dosing
First and only feline broad spectrum parasite protection that treats tapeworms.
Protects against adult fleas before they can lay eggs while protecting against black-legged ticks and lone star ticks
Effectively prevents heartworm disease while treating and controlling hookworms, roundworms, and tapeworms

9.5

Excellent

Frontline

FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

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Main Highlights

FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
Treat cats and dogs in the home monthly to effectively control fleas and ticks and prevent the establishment of new infestations
Subscribe & save today to make it easier to keep your cat or dog protected year-round and make sure you never run out of FRONTLINE Plus

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Main Highlights

FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
Treat cats and dogs in the home monthly to effectively control fleas and ticks and prevent the establishment of new infestations
Subscribe & save today to make it easier to keep your cat or dog protected year-round and make sure you never run out of FRONTLINE Plus

9.2

Excellent

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 6-Month Supply

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Main Highlights

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

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Main Highlights

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

9.0

Excellent

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply

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Main Highlights

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

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Main Highlights

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

8.8

Very Good

Advantage

Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

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Main Highlights

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

Check Price

Main Highlights

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

8.6

Very Good

PetArmor

PetArmor Plus Flea and Tick Prevention for Cats over 1.5 lbs, Cat Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting

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Main Highlights

EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months

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Main Highlights

EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months

8.3

Very Good

Advantage

Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 2-Month Supply

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Main Highlights

Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

Check Price

Main Highlights

Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment no hard-to-swallow pills, no prescription needed
Delivers total flea protection kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

8.1

Very Good

PetArmor

PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Cat Flea Treatment Pill, Fast Acting Tablets Start Killing in 30 Minutes, 2-25 lbs, 6 Doses

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Main Highlights

FAST-ACTING: One oral cat flea pill starts killing fleas within 30 minutes of administration
SAFE TO USE: This cat oral flea treatment is safe for kittens and cats from 2-25 lbs; 4 weeks and older, when used as directed
TREAT RE-INFESTATIONS FAST: If your pet gets reinfested with fleas simply apply another dose as often as once a day; CAPACTION Cat Flea Pills are even safe for use on pregnant or breeding cats
EASY TO USE KITTEN FLEA TREATMENT: Without the mess and rubbing off of a flea and tick topical treatment and without the need of a veterinarian prescription, this oral cat flea treatment is administered orally to kill adult fleas fast
KILL FLEAS EFFICIENTLY: Includes 6 doses of CAPACTION for cats, killing adult fleas that may cause allergy dermatitis

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Main Highlights

FAST-ACTING: One oral cat flea pill starts killing fleas within 30 minutes of administration
SAFE TO USE: This cat oral flea treatment is safe for kittens and cats from 2-25 lbs; 4 weeks and older, when used as directed
TREAT RE-INFESTATIONS FAST: If your pet gets reinfested with fleas simply apply another dose as often as once a day; CAPACTION Cat Flea Pills are even safe for use on pregnant or breeding cats
EASY TO USE KITTEN FLEA TREATMENT: Without the mess and rubbing off of a flea and tick topical treatment and without the need of a veterinarian prescription, this oral cat flea treatment is administered orally to kill adult fleas fast
KILL FLEAS EFFICIENTLY: Includes 6 doses of CAPACTION for cats, killing adult fleas that may cause allergy dermatitis

8.1

Very Good

Elanco

Elanco Tapeworm Dewormer (praziquantel tablets) for Cats and Kittens 6 Weeks and Older, 3-count

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Main Highlights

3-count bottle of tapeworm dewormer for cats
Easy effective way to remove common tapeworms in cats
Tablets may be crumbled and mixed with food or taken by mouth
Tapeworm Dewormer for Cats will remove the common tapeworms, Dipylidium caninum and Taenia taeniaeformis, from cats and kittens
For use in cats over 6 weeks of age
Easy and effective way to remove common tapeworms from cats

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Main Highlights

3-count bottle of tapeworm dewormer for cats
Easy effective way to remove common tapeworms in cats
Tablets may be crumbled and mixed with food or taken by mouth
Tapeworm Dewormer for Cats will remove the common tapeworms, Dipylidium caninum and Taenia taeniaeformis, from cats and kittens
For use in cats over 6 weeks of age
Easy and effective way to remove common tapeworms from cats

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