Updated:March, 2026

10 Best Eye Drops Preservative Free Allergy of 2026

Best Choice

9.9

Outstanding

Opcon-A

Opcon-A Allergy Eye Drops, Antihistamine and Redness Relief for Itchy, Red Eyes, Soothes Irritation from Pollen, Ragweed, Grass, Animal Hair and Dander Clinically Proven Formula, 0.5 Fl Oz (Pack of 2)

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Why We Love It

EYE DROPS FOR ALLERGIES AND EYE ITCHING: Opcon A eye drops combine an antihistamine with a redness reliever to help relieve itchy, red, irritated eyes. Temporary relief from itching & redness caused by pollen, ragweed, grass, animal hair & dander
RELIEF FOR ITCHY EYES : These allergy relief eye drops are clinically proven to provide effective relief of redness & itching caused by allergens. These allergy eye drops can be used up to four times a day to give temporary relief from symptoms
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

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Why We Love It

EYE DROPS FOR ALLERGIES AND EYE ITCHING: Opcon A eye drops combine an antihistamine with a redness reliever to help relieve itchy, red, irritated eyes. Temporary relief from itching & redness caused by pollen, ragweed, grass, animal hair & dander
RELIEF FOR ITCHY EYES : These allergy relief eye drops are clinically proven to provide effective relief of redness & itching caused by allergens. These allergy eye drops can be used up to four times a day to give temporary relief from symptoms
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation & quality in our eye care products, from contact lenses & solutions to eye drops, ointments, eye vitamins & more
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help make sure your eyes feel healthy, moisturized, & protected

How We Find the Top Picks

We use smart data tools to review thousands of products and stores, analyzing ratings, reviews, and popularity trends to highlight what truly matters to shoppers like you.

Our experts then refine the results, blending AI insights with real user experiences to deliver accurate, up-to-date rankings that help you choose with confidence.

9.5

Excellent

Optase

OPTASE Allegro Lubricant Eye Drops, 0.33 fl oz – Preservative Free Eye Drops for Dry Eyes – Artificial Tears for Environmental Irritants - Contact Lens Compatible - Multidose Bottle Contains 300 Doses

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Main Highlights

HYDRATES AND SUPPORTS: Allegro's preservative-free HEC formula works with your natural tears to lubricate eyes and support a gentle protective barrier against environmental irritants for daily comfort
PRESERVATIVE FREE EYE DROPS: OPTASE Allegro preservative free eye drops provide soothing lubrication for dryness caused by environmental irritants, supporting comfortable moisture throughout the day
MULTIDOSE BOTTLE DESIGN: Thoughtfully engineered multidose bottle delivers up to 300 precise drops, supporting clean, controlled dispensing while helping maintain product sterility for up to 3 months
CONTACT LENS COMPATIBLE: Gentle lubricating drops suitable for use with most contact lens types, designed to maintain comfort and convenience without residue or clouding for use throughout the day
OPTASE EYE CARE EXPERTISE: Part of the OPTASE eye care line, created with a focus on gentle, preservative free hydration and backed by science-led formulations to support everyday comfort and wellness

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Main Highlights

HYDRATES AND SUPPORTS: Allegro's preservative-free HEC formula works with your natural tears to lubricate eyes and support a gentle protective barrier against environmental irritants for daily comfort
PRESERVATIVE FREE EYE DROPS: OPTASE Allegro preservative free eye drops provide soothing lubrication for dryness caused by environmental irritants, supporting comfortable moisture throughout the day
MULTIDOSE BOTTLE DESIGN: Thoughtfully engineered multidose bottle delivers up to 300 precise drops, supporting clean, controlled dispensing while helping maintain product sterility for up to 3 months
CONTACT LENS COMPATIBLE: Gentle lubricating drops suitable for use with most contact lens types, designed to maintain comfort and convenience without residue or clouding for use throughout the day
OPTASE EYE CARE EXPERTISE: Part of the OPTASE eye care line, created with a focus on gentle, preservative free hydration and backed by science-led formulations to support everyday comfort and wellness

9.5

Excellent

Alaway

Alaway Antihistamine Eye Drops for Itchy Eyes, Fast-Acting, Up to 12-Hour Eye Itch Relief, Clinically Tested Prescription-Strength Formula, 0.34 Fl Oz (Pack of 2)

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Main Highlights

Alaway Eye Itch Relief: Fast-acting antihistamine eye drops help relieve itchy eyes from pollen, ragweed, grass, pet hair, and dander. These allergy eye drops with ketotifen provide up to 12 hours of allergy relief.
Antihistamine Eye Drops: Clinically tested allergy eye itch medicine delivers fast-acting relief for itchy eyes. This prescription-strength eyedrops formula works at the source of eye itch symptoms.
Allergy Eye Care: Seasonal and all year allergy eyedrops provide fast relief from itchy eyes. This allergy medicine works in minutes at the source of eye itch symptoms. Perfect for on-the-go relief for adults and kids over 3.
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help your eyes feel healthy, moisturized, & protected

Check Price

Main Highlights

Alaway Eye Itch Relief: Fast-acting antihistamine eye drops help relieve itchy eyes from pollen, ragweed, grass, pet hair, and dander. These allergy eye drops with ketotifen provide up to 12 hours of allergy relief.
Antihistamine Eye Drops: Clinically tested allergy eye itch medicine delivers fast-acting relief for itchy eyes. This prescription-strength eyedrops formula works at the source of eye itch symptoms.
Allergy Eye Care: Seasonal and all year allergy eyedrops provide fast relief from itchy eyes. This allergy medicine works in minutes at the source of eye itch symptoms. Perfect for on-the-go relief for adults and kids over 3.
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help your eyes feel healthy, moisturized, & protected

9.2

Excellent

Alaway

Alaway Antihistamine Eye Drops for Itchy Eyes, Fast-Acting, Up to 12-Hour Eye Itch Relief, Clinically Tested Prescription-Strength Formula, 0.34 Fl Oz

Free Shipping

Main Highlights

Alaway Eye Itch Relief: Fast-acting antihistamine eye drops help relieve itchy eyes from pollen, ragweed, grass, pet hair, and dander. These allergy eye drops with ketotifen provide up to 12 hours of allergy relief.
Antihistamine Eye Drops: Clinically tested allergy eye itch medicine delivers fast-acting relief for itchy eyes. This prescription-strength eyedrops formula works at the source of eye itch symptoms.
Allergy Eye Care: Seasonal and all year allergy eyedrops provide fast relief from itchy eyes. This allergy medicine works in minutes at the source of eye itch symptoms. Perfect for on-the-go relief for adults and kids over 3.
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help your eyes feel healthy, moisturized, & protected

Check Price

Main Highlights

Alaway Eye Itch Relief: Fast-acting antihistamine eye drops help relieve itchy eyes from pollen, ragweed, grass, pet hair, and dander. These allergy eye drops with ketotifen provide up to 12 hours of allergy relief.
Antihistamine Eye Drops: Clinically tested allergy eye itch medicine delivers fast-acting relief for itchy eyes. This prescription-strength eyedrops formula works at the source of eye itch symptoms.
Allergy Eye Care: Seasonal and all year allergy eyedrops provide fast relief from itchy eyes. This allergy medicine works in minutes at the source of eye itch symptoms. Perfect for on-the-go relief for adults and kids over 3.
BAUSCH +LOMB EYE DROPS: Whether you have dry eyes, red eyes, itchy eyes, or all of the above, we offer a variety of options for your needs, including lubricating & preservative-free eye drops
EYE DROPS & MORE: Bausch + Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, & ointments to help your eyes feel healthy, moisturized, & protected

9.0

Excellent

Systane

Systane Ultra PF Preservative-Free Eye Drops 10ml

Free Shipping

Main Highlights

Preservative-Free Lubricant Eye Drops
Fast-Acting Hydration and lasting dry eye relief
Moisture rich formula for sensitive eyes
Tear evaporation protection

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Main Highlights

Preservative-Free Lubricant Eye Drops
Fast-Acting Hydration and lasting dry eye relief
Moisture rich formula for sensitive eyes
Tear evaporation protection

8.8

Very Good

LUMIFY

LUMIFY Preservative Free Eye Drops for Red Eyes, Redness Reliever for Sensitive Eye, Brighter and Whiter Looking Eyes, Works in 1 Minute & Lasts Up to 8 Hours, 20 Single-Use Vials

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Main Highlights

EYE DROPS FOR RED EYES: From the eye care experts at Bausch + Lomb, LUMIFY Preservative Free Eye Drops help restore your eyes natural whiteness & reveal your eyes' natural radiance. These red eye drops work within 1 minute & last up to 8 hours
PRESERVATIVE FREE EYE DROPS: Compared to other redness relief eye drops, LUMIFY is the only OTC eye drop to contain low-dose brimonidine that selectively targets redness & helps lower risk of certain side effects seen with other OTC redness relievers when used as directed
PRESERVATIVE FREE REDNESS RELIEVER: The LUMIFY eye drops do not contain bleach or dyes. 95% showed significant redness reduction in 1 minute. They are the first and only preservative free redness reliever eye drops and are formulated to be gentle on sensitive eyes
AMAZING LOOKING EYES: We understand how important eyes are and despite all eye creams, mascara, eyeliners, and eyeshadows, you wont look your best with red eyes. Our redness relief eye drops help eyes look brighter and whiter to help restore their natural glow
DEVELOPED BY EYE CARE EXPERTS: For over 150 years, the experts at Bausch + Lomb have focused on innovation & quality in eye care products, from contact lenses and solutions to eye drops for allergies and eye itching, ointments, eye vitamins, and more

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Main Highlights

EYE DROPS FOR RED EYES: From the eye care experts at Bausch + Lomb, LUMIFY Preservative Free Eye Drops help restore your eyes natural whiteness & reveal your eyes' natural radiance. These red eye drops work within 1 minute & last up to 8 hours
PRESERVATIVE FREE EYE DROPS: Compared to other redness relief eye drops, LUMIFY is the only OTC eye drop to contain low-dose brimonidine that selectively targets redness & helps lower risk of certain side effects seen with other OTC redness relievers when used as directed
PRESERVATIVE FREE REDNESS RELIEVER: The LUMIFY eye drops do not contain bleach or dyes. 95% showed significant redness reduction in 1 minute. They are the first and only preservative free redness reliever eye drops and are formulated to be gentle on sensitive eyes
AMAZING LOOKING EYES: We understand how important eyes are and despite all eye creams, mascara, eyeliners, and eyeshadows, you wont look your best with red eyes. Our redness relief eye drops help eyes look brighter and whiter to help restore their natural glow
DEVELOPED BY EYE CARE EXPERTS: For over 150 years, the experts at Bausch + Lomb have focused on innovation & quality in eye care products, from contact lenses and solutions to eye drops for allergies and eye itching, ointments, eye vitamins, and more

8.6

Very Good

Refresh

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

Free Shipping

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

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Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

8.3

Very Good

Bausch + Lomb

Bausch + Lomb Advanced Eye Relief, Olopatadine 0.2% Antihistamine Eye Drops for Eye Allergy Itch Relief, Once-Daily Prescription Strength 16-Hour Relief, 0.12 Fl Oz

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Main Highlights

FAST EYE ALLERGY ITCH RELIEF: This 0.2% olopatadine eye drops for allergies is designed to address eye irritation from allergens like pollen, pet dander, grass, and ragweed, offering targeted care for itchy eyes
ONCE-DAILY APPLICATION: The once-daily eye drops start working in minutes to alleviate eye allergy itch for up to 16 hours. These antihistamine eye drops support long-lasting comfort and fit seamlessly into your daily routine
TRUSTED PRESCRIPTION-STRENGTH FORMULA: With Olopatadine 0.2% Hydrochloride solution, an antihistamine, these eye allergy itch relief drops deliver the same efficacy as original prescription-strength formula
A SELECTION OF EYE DROPS FOR EVERY NEED: Whether you have dry, red, or itchy eyes or all of the above, Bausch + Lomb offers a variety of options for your needs, including lubricating and preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation and quality in our eye care products, from contact lenses and solutions to eye drops, ointments, eye vitamins and more, so your eyes feel healthy, moisturized, & protected

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Main Highlights

FAST EYE ALLERGY ITCH RELIEF: This 0.2% olopatadine eye drops for allergies is designed to address eye irritation from allergens like pollen, pet dander, grass, and ragweed, offering targeted care for itchy eyes
ONCE-DAILY APPLICATION: The once-daily eye drops start working in minutes to alleviate eye allergy itch for up to 16 hours. These antihistamine eye drops support long-lasting comfort and fit seamlessly into your daily routine
TRUSTED PRESCRIPTION-STRENGTH FORMULA: With Olopatadine 0.2% Hydrochloride solution, an antihistamine, these eye allergy itch relief drops deliver the same efficacy as original prescription-strength formula
A SELECTION OF EYE DROPS FOR EVERY NEED: Whether you have dry, red, or itchy eyes or all of the above, Bausch + Lomb offers a variety of options for your needs, including lubricating and preservative-free eye drops
EYE CARE EXPERTS: For over 150 years, Bausch + Lomb has focused on innovation and quality in our eye care products, from contact lenses and solutions to eye drops, ointments, eye vitamins and more, so your eyes feel healthy, moisturized, & protected

8.1

Very Good

Systane

Systane PRO PF Multi-dose Preservative-Free Lubricant Eye Drops 2 Count

Free Shipping

Main Highlights

Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for up to 12 hours of relief
Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated to support extended hydration for all types of dry eye relief
Tear Evaporation Protection: This unique formula helps lock in moisture and reduce tear evaporation
Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief
Convenient Size: The 10mL bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
Contact Lens Friendly*: safe for use with soft contact lenses

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Main Highlights

Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for up to 12 hours of relief
Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated to support extended hydration for all types of dry eye relief
Tear Evaporation Protection: This unique formula helps lock in moisture and reduce tear evaporation
Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief
Convenient Size: The 10mL bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
Contact Lens Friendly*: safe for use with soft contact lenses

8.1

Very Good

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 10ml

Free Shipping

Main Highlights

Fast acting hydration for sensitive eyes
Preservative free tear evaporation protection
Nano droplets for better coverage

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Main Highlights

Fast acting hydration for sensitive eyes
Preservative free tear evaporation protection
Nano droplets for better coverage

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