Updated:March, 2026

10 Best Digestive Enzymes With No Gallbladder of 2026

Best Choice

9.9

Outstanding

Dr. Mercola

Dr. Mercola Gallbladder Enzymes - Gallbladder & Digestive Health Support - Includes Pancreatic Protease, Amylase & Lipase - Non-GMO, Gluten-Free & Soy-Free - 30 Delayed Release Capsules (30 Servings)

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Why We Love It

Digestive Enzymes: This enzyme blend includes a high-activity blend of Pancreatic Protease, Amylase, and Lipase
Delayed Release: Our formula uses delayed release capsules to protect enzymes from stomach acids
Digestion Supplement: This dietary supplement also features Ox Bile and ATP for further digestive support*
Empowering You: We give you the resources to take control of your health with regenerative practices and informed consent principles

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Why We Love It

Digestive Enzymes: This enzyme blend includes a high-activity blend of Pancreatic Protease, Amylase, and Lipase
Delayed Release: Our formula uses delayed release capsules to protect enzymes from stomach acids
Digestion Supplement: This dietary supplement also features Ox Bile and ATP for further digestive support*
Empowering You: We give you the resources to take control of your health with regenerative practices and informed consent principles

How We Find the Top Picks

We use smart data tools to review thousands of products and stores, analyzing ratings, reviews, and popularity trends to highlight what truly matters to shoppers like you.

Our experts then refine the results, blending AI insights with real user experiences to deliver accurate, up-to-date rankings that help you choose with confidence.

9.5

Excellent

Natures Craft

Digestive Enzymes with Ox Bile - Ox Bile Supplements for No Gallbladder with Trypsin, Papain & Bromelain Enzyme for Pancrease Cleanse & Detox - Pancreatin Digestion Enzymes for Women & Men - 90 Ct

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Main Highlights

ADVANCED ENZYMES FOR DIGESTION Our pancreatic enzymes are designed for individuals with no gallbladder or compromised bile production. These ox bile digestive enzymes provide enzymatic support to aid fat digestion, nutrient absorption, and digestive comfort for both men and women.
PROMOTES GUT & PANCREAS HEALTH Our comprehensive digestive enzymes for women & men support optimal digestion and pancreas function, helping to break down fats, proteins, and carbohydrates for improved gut balance, reduced bloating, and enhanced nutrient uptake.
POWERFUL ENZYME BLEND Featuring ox bile, trypsin, pancreatin digestive enzymes, bromelain & papain enzyme & peptidase, our digestive enzymes for men & women work synergistically to support bile flow, aid digestion & promote gut health, making it an ideal support for those without a gallbladder.
HOW TO USE & WARNINGS Take the recommended daily dosage of our bile salts gallbladder supplements to support digestion & nutrient absorption. Consult a healthcare professional before use, especially if taking medications or managing health conditions. Not for children or pregnant women.
MADE IN THE USA WITH GLOBALLY SOURCED INGREDIENTS Our bile salts for no gallbladder are proudly made in the USA in a GMP-compliant facility. This 3rd-party lab-tested digestion supplement is non-GMO and crafted with high-quality, natural ingredients to provide safety, potency & effectiveness.

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Main Highlights

ADVANCED ENZYMES FOR DIGESTION Our pancreatic enzymes are designed for individuals with no gallbladder or compromised bile production. These ox bile digestive enzymes provide enzymatic support to aid fat digestion, nutrient absorption, and digestive comfort for both men and women.
PROMOTES GUT & PANCREAS HEALTH Our comprehensive digestive enzymes for women & men support optimal digestion and pancreas function, helping to break down fats, proteins, and carbohydrates for improved gut balance, reduced bloating, and enhanced nutrient uptake.
POWERFUL ENZYME BLEND Featuring ox bile, trypsin, pancreatin digestive enzymes, bromelain & papain enzyme & peptidase, our digestive enzymes for men & women work synergistically to support bile flow, aid digestion & promote gut health, making it an ideal support for those without a gallbladder.
HOW TO USE & WARNINGS Take the recommended daily dosage of our bile salts gallbladder supplements to support digestion & nutrient absorption. Consult a healthcare professional before use, especially if taking medications or managing health conditions. Not for children or pregnant women.
MADE IN THE USA WITH GLOBALLY SOURCED INGREDIENTS Our bile salts for no gallbladder are proudly made in the USA in a GMP-compliant facility. This 3rd-party lab-tested digestion supplement is non-GMO and crafted with high-quality, natural ingredients to provide safety, potency & effectiveness.

9.5

Excellent

Natures Craft

Gallbladder Support Digestive Enzymes with Ox Bile - Purified Ox Bile Salts for No Gallbladder & Pancreas Cleanse, Detox & Repair - Digestion Supplement with Pancreatin & Chanca Piedra - 90 Count

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Main Highlights

Advanced Gallbladder Formula - Say hello to our one of a kind gallbladder supplements with Ox bile Digestive enzymes and Bile salts for no gallbladder or compromised gall or pancreatic enzymes
Unique Complex - We combined Chanca Piedra Betaine Ox bile 500mg and Gallbladder enzymes to provide digestive support including Indigestion Bloating Fatty food intolerance and other GI discomfort
Multipurpose Gallbladder Support - This is no ordinary digestion supplement since our cutting edge gallbladder complex can be used as a Stone breaker Kidney & gallbladder cleanse detox & repair
Trusted Brand - Forget about generic products and put your trust in our 3rd party ISO Lab Verified digestive enzyme supplements made in GMP American facilities without unnecessary fillers
Natures Craft Quality - We are proud to be a leading name in a variety of digestion and bloating supplements because we know just how important gut health can be for adults to feel their best

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Main Highlights

Advanced Gallbladder Formula - Say hello to our one of a kind gallbladder supplements with Ox bile Digestive enzymes and Bile salts for no gallbladder or compromised gall or pancreatic enzymes
Unique Complex - We combined Chanca Piedra Betaine Ox bile 500mg and Gallbladder enzymes to provide digestive support including Indigestion Bloating Fatty food intolerance and other GI discomfort
Multipurpose Gallbladder Support - This is no ordinary digestion supplement since our cutting edge gallbladder complex can be used as a Stone breaker Kidney & gallbladder cleanse detox & repair
Trusted Brand - Forget about generic products and put your trust in our 3rd party ISO Lab Verified digestive enzyme supplements made in GMP American facilities without unnecessary fillers
Natures Craft Quality - We are proud to be a leading name in a variety of digestion and bloating supplements because we know just how important gut health can be for adults to feel their best

9.2

Excellent

Dr. Berg Nutritionals

Dr. Berg Gallbladder Formula Extra Strength - with Ox Bile Powder and Conjugated Bile Acid - Digestive Enzymes Proprietary Blend - Full 45-Day Supply - 90 Vegetable Capsules

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Main Highlights

This gallbladder formula is made with ox bile powder, conjugated bile acid, and a proprietary blend of digestive enzymes. Recommended 2 capsules per day with a meal. Includes 90 capsules (45-day supply).
- Our state-of-the-art manufacturing facilities are located in the US and are staffed with highly trained individuals who formulate superior products. Being certified under US laws and regulations (GMP Certified), these facilities are uncompromising when it comes to cleanliness and quality control.
- We're sorry to say it, but if youre looking for cheap, youre in the wrong place. We search far and wide, domestic and international, to provide high-quality ingredients for which your body will thank you. Unfortunately, getting the best ingredients from domestic and international farms can come at a higher-than-normal cost. If quality, satisfaction, and results are essential to you, youre in the right place!
- Also known as The Knowledge Doc, Dr. Berg has spent most of his life researching and providing natural solutions to everyday health problems. This extensive research and thousands of hours working with patients are what sets us apart from other brands, as it has allowed us to create proprietary blends you cant get anywhere else.
- - If for any reason you're not happy with the results you experience within the first 30 days, we're happy to give you a full refund! Send us a message, and the refund will be processed as long as it's requested within 30 days of purchase.

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Main Highlights

This gallbladder formula is made with ox bile powder, conjugated bile acid, and a proprietary blend of digestive enzymes. Recommended 2 capsules per day with a meal. Includes 90 capsules (45-day supply).
- Our state-of-the-art manufacturing facilities are located in the US and are staffed with highly trained individuals who formulate superior products. Being certified under US laws and regulations (GMP Certified), these facilities are uncompromising when it comes to cleanliness and quality control.
- We're sorry to say it, but if youre looking for cheap, youre in the wrong place. We search far and wide, domestic and international, to provide high-quality ingredients for which your body will thank you. Unfortunately, getting the best ingredients from domestic and international farms can come at a higher-than-normal cost. If quality, satisfaction, and results are essential to you, youre in the right place!
- Also known as The Knowledge Doc, Dr. Berg has spent most of his life researching and providing natural solutions to everyday health problems. This extensive research and thousands of hours working with patients are what sets us apart from other brands, as it has allowed us to create proprietary blends you cant get anywhere else.
- - If for any reason you're not happy with the results you experience within the first 30 days, we're happy to give you a full refund! Send us a message, and the refund will be processed as long as it's requested within 30 days of purchase.

9.0

Excellent

Pure Encapsulations

Pure Encapsulations Digestion GB - Digestive Enzyme Supplement - for Gallbladder Support & Gut Health* - with Bile Salts & Digestive Enzymes Blend - Gluten Free & Non-GMO - 180 Capsules

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Main Highlights

Gallbladder Support: Digestion GB Features digestive enzymes, bile salts, and taurine for optimal gallbladder function, digestive function, and lipid utilization*
Enzyme Blend: Provides protease, lipase, and amylase, all digestive enzymes, to aid the digestion of lipids*
Liver Health: Milk thistle and turmeric extracts support the liver and bile production, complemented by digestive enzymes*
Suggested Use: As a dietary supplement, take 2 gallbladder health capsules, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

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Main Highlights

Gallbladder Support: Digestion GB Features digestive enzymes, bile salts, and taurine for optimal gallbladder function, digestive function, and lipid utilization*
Enzyme Blend: Provides protease, lipase, and amylase, all digestive enzymes, to aid the digestion of lipids*
Liver Health: Milk thistle and turmeric extracts support the liver and bile production, complemented by digestive enzymes*
Suggested Use: As a dietary supplement, take 2 gallbladder health capsules, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

8.8

Very Good

LionHeart Supplements

Digestive Enzymes with ox Bile - Supplements for No Gallbladder - Helps Digest Meals Small or Large - Including HCL - Pepsin - Papain & Bromelain - Purified Bile Salts - Gallbladder Support 60ct

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Main Highlights

DIGESTIVE COMFORT AFTER MEALS Enzyme + 7 is made for people who deal with occasional bloating, gas, heaviness, or irregularity after eating. It supports smoother digestion so you can feel more comfortable, more oftenwithout overthinking every meal.
FEEL LIGHTER AFTER YOU EAT A 7-enzyme blend with Pepsin and Bromelain to support comfortable digestion and ease that sitting heavy feeling after meals. Great for anyone who feels bloated, gassy, or uncomfortable after normal foods.
GALLBLADDER + STOMACH SUPPORT (OX BILE 30mg + HCL 100mg) Formulated for people with gallbladder issues or removal. Ox Bile supports comfort after richer meals, while HCL (100mg) helps support healthy stomach acid levelsimportant for smooth digestion and that food just sitting there feeling.
ENTERIC COATED FOR BETTER TIMING Not all enzyme tablets are created equal. Our enteric coating is designed for delayed release, helping the tablet reach the right place before it starts workingso you get support when you actually need it.
DOCTOR FORMULATED + SIMPLE DAILY ROUTINE Made to fit real life: take 1 tablet with every meal to support daily digestive comfort and confidence. Includes 7 enzymes, plus Pepsin, Bromelain, Ox Bile (30mg) and HCL (100mg) as part of the complete formula.

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Main Highlights

DIGESTIVE COMFORT AFTER MEALS Enzyme + 7 is made for people who deal with occasional bloating, gas, heaviness, or irregularity after eating. It supports smoother digestion so you can feel more comfortable, more oftenwithout overthinking every meal.
FEEL LIGHTER AFTER YOU EAT A 7-enzyme blend with Pepsin and Bromelain to support comfortable digestion and ease that sitting heavy feeling after meals. Great for anyone who feels bloated, gassy, or uncomfortable after normal foods.
GALLBLADDER + STOMACH SUPPORT (OX BILE 30mg + HCL 100mg) Formulated for people with gallbladder issues or removal. Ox Bile supports comfort after richer meals, while HCL (100mg) helps support healthy stomach acid levelsimportant for smooth digestion and that food just sitting there feeling.
ENTERIC COATED FOR BETTER TIMING Not all enzyme tablets are created equal. Our enteric coating is designed for delayed release, helping the tablet reach the right place before it starts workingso you get support when you actually need it.
DOCTOR FORMULATED + SIMPLE DAILY ROUTINE Made to fit real life: take 1 tablet with every meal to support daily digestive comfort and confidence. Includes 7 enzymes, plus Pepsin, Bromelain, Ox Bile (30mg) and HCL (100mg) as part of the complete formula.

8.6

Very Good

LionHeart Supplements

Digestive Enzymes Supplement with Ox Bile Salts 30mg - Betaine HCl 100mg - Supports Digestion, Gas & Bloating - Gallbladder Support (No Gallbladder) - Doctor Formulated - For Men & Women - 90 Tablet

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Main Highlights

DIGESTIVE COMFORT AFTER MEALS Enzyme + 7 is made for people who deal with occasional bloating, gas, heaviness, or irregularity after eating. It supports smoother digestion so you can feel more comfortable, more oftenwithout overthinking every meal.
FEEL LIGHTER AFTER YOU EAT A 7-enzyme blend with Pepsin and Bromelain to support comfortable digestion and ease that sitting heavy feeling after meals. Great for anyone who feels bloated, gassy, or uncomfortable after normal foods.
GALLBLADDER + STOMACH SUPPORT (OX BILE 30mg + HCL 100mg) Formulated for people with gallbladder issues or removal. Ox Bile supports comfort after richer meals, while HCL (100mg) helps support healthy stomach acid levelsimportant for smooth digestion and that food just sitting there feeling.
ENTERIC COATED FOR BETTER TIMING Not all enzyme tablets are created equal. Our enteric coating is designed for delayed release, helping the tablet reach the right place before it starts workingso you get support when you actually need it.
DOCTOR FORMULATED + SIMPLE DAILY ROUTINE Made to fit real life: take 1 tablet with every meal to support daily digestive comfort and confidence. Includes 7 enzymes, plus Pepsin, Bromelain, Ox Bile (30mg) and HCL (100mg) as part of the complete formula.

Check Price

Main Highlights

DIGESTIVE COMFORT AFTER MEALS Enzyme + 7 is made for people who deal with occasional bloating, gas, heaviness, or irregularity after eating. It supports smoother digestion so you can feel more comfortable, more oftenwithout overthinking every meal.
FEEL LIGHTER AFTER YOU EAT A 7-enzyme blend with Pepsin and Bromelain to support comfortable digestion and ease that sitting heavy feeling after meals. Great for anyone who feels bloated, gassy, or uncomfortable after normal foods.
GALLBLADDER + STOMACH SUPPORT (OX BILE 30mg + HCL 100mg) Formulated for people with gallbladder issues or removal. Ox Bile supports comfort after richer meals, while HCL (100mg) helps support healthy stomach acid levelsimportant for smooth digestion and that food just sitting there feeling.
ENTERIC COATED FOR BETTER TIMING Not all enzyme tablets are created equal. Our enteric coating is designed for delayed release, helping the tablet reach the right place before it starts workingso you get support when you actually need it.
DOCTOR FORMULATED + SIMPLE DAILY ROUTINE Made to fit real life: take 1 tablet with every meal to support daily digestive comfort and confidence. Includes 7 enzymes, plus Pepsin, Bromelain, Ox Bile (30mg) and HCL (100mg) as part of the complete formula.

8.3

Very Good

Pure Encapsulations

Pure Encapsulations Digestion GB - Digestive Enzyme Supplement - for Gallbladder Support & Gut Health* - with Bile Salts & Digestive Enzymes Blend - Gluten Free & Non-GMO - 90 Capsules

Free Shipping

Main Highlights

Gallbladder Support: Digestion GB Features digestive enzymes, bile salts, and taurine for optimal gallbladder function, digestive function, and lipid utilization*
Enzyme Blend: Provides protease, lipase, and amylase, all digestive enzymes, to aid the digestion of lipids*
Liver Health: Milk thistle and turmeric extracts support the liver and bile production, complemented by digestive enzymes*
Suggested Use: As a dietary supplement, take 2 gallbladder health capsules, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

Check Price

Main Highlights

Gallbladder Support: Digestion GB Features digestive enzymes, bile salts, and taurine for optimal gallbladder function, digestive function, and lipid utilization*
Enzyme Blend: Provides protease, lipase, and amylase, all digestive enzymes, to aid the digestion of lipids*
Liver Health: Milk thistle and turmeric extracts support the liver and bile production, complemented by digestive enzymes*
Suggested Use: As a dietary supplement, take 2 gallbladder health capsules, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

8.1

Very Good

BIOTICS RESEARCH

Biotics Research Beta-Plus™ Nutritional Ox Bile Salts Digestive Enzymes Supplement For Bile Production For No Gallbladder-Supports Overall Liver Function, Aids Fat Digestion, Supplies Betaine 180 Tabs

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Main Highlights

SUPPORTS HEALTHY CHOLESTEROL LEVELS: Beta-Plus supplies necessary nutrients that have been found to support good cholesterol and triglyceride conversion and utilization
OPTIMAL FAT DIGESTION: Bile insufficiency has been associated with generalized intolerance of fatty foods; Beta-Plus is designed to support optimal digestion and assimilation of dietary fats and fat-soluble vitamins; Beta-Plus includes pancreatic lipase, an enzyme that significantly improves the fat digestive process
SUPPORTS HEALTHY BILE PRODUCTION: Bile serves as a fat emulsifier, allowing fat to become water-soluble and better absorbed; Each tablet of Beta Plus supplies 100 mg of Ox bile extract combined with pancrelipase and organic whole beet concentrate, offering effective digestive support, particularly for those people who have had their gall bladders removed and are at risk for bile insufficiency
WHO WE ARE: We have revolutionized the nutritional supplement industry by combining The Best of Science and Nature"; Our focus on research, natural effectiveness, product safety, efficacy, quality control, and ongoing innovation drives our advancements in the field
QUALITY MADE IN THE USA: We produce tablets, capsules, powders, and liquids in a Texas Department of Health licensed, GMP-certified production and ISO-certified laboratory facility; All products are tested in a state-of-the-art laboratory to ensure safety, efficacy, and purity, and are Gluten Free!

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Main Highlights

SUPPORTS HEALTHY CHOLESTEROL LEVELS: Beta-Plus supplies necessary nutrients that have been found to support good cholesterol and triglyceride conversion and utilization
OPTIMAL FAT DIGESTION: Bile insufficiency has been associated with generalized intolerance of fatty foods; Beta-Plus is designed to support optimal digestion and assimilation of dietary fats and fat-soluble vitamins; Beta-Plus includes pancreatic lipase, an enzyme that significantly improves the fat digestive process
SUPPORTS HEALTHY BILE PRODUCTION: Bile serves as a fat emulsifier, allowing fat to become water-soluble and better absorbed; Each tablet of Beta Plus supplies 100 mg of Ox bile extract combined with pancrelipase and organic whole beet concentrate, offering effective digestive support, particularly for those people who have had their gall bladders removed and are at risk for bile insufficiency
WHO WE ARE: We have revolutionized the nutritional supplement industry by combining The Best of Science and Nature"; Our focus on research, natural effectiveness, product safety, efficacy, quality control, and ongoing innovation drives our advancements in the field
QUALITY MADE IN THE USA: We produce tablets, capsules, powders, and liquids in a Texas Department of Health licensed, GMP-certified production and ISO-certified laboratory facility; All products are tested in a state-of-the-art laboratory to ensure safety, efficacy, and purity, and are Gluten Free!

8.1

Very Good

Seeking Health

Seeking Health Ox Bile 125 - Digestive Enzyme & Gallbladder Support Supplement - Vegetarian Capsule with Digestive Enzymes - 120 Capsules

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Main Highlights

Ox Bile Supplement: Each digestive enzyme supplement contains 125 mg of pure ox bile to support healthy balance of small intestinal environment
Enzyme for Digestion Support: Our digestion supplement formula includes a 40% cholic acid component for targeted fat digestion support
Digestive Supplement for Flexible Usage: This digestion supplement can be taken with high-fat meals or without food; ideal for those with gallbladder removed
Allergen-Friendly Digestive Support: This ox bile supplement is free of gmos, gluten, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame, and soy
Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust

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Main Highlights

Ox Bile Supplement: Each digestive enzyme supplement contains 125 mg of pure ox bile to support healthy balance of small intestinal environment
Enzyme for Digestion Support: Our digestion supplement formula includes a 40% cholic acid component for targeted fat digestion support
Digestive Supplement for Flexible Usage: This digestion supplement can be taken with high-fat meals or without food; ideal for those with gallbladder removed
Allergen-Friendly Digestive Support: This ox bile supplement is free of gmos, gluten, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame, and soy
Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust

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