Updated:March, 2026

10 Best Best Pancreatic Enzyme Supplements Over The Counter of 2026

Best Choice

9.9

Outstanding

Vital Nutrients

Vital Nutrients Pancreatic Enzymes 1000mg (Full Strength) - Pancreatin Digestion Supplement with Protease, Amylase & Lipase - Digestive Enzymes - Gluten, Dairy, and Soy Free - 90 Capsules

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Why We Love It

Premium Digestive Enzyme Supplement: Supports gut health, digestion, and bowel regularity with one easy-to-swallow capsule taken with meals. Helps support relief from occasional indigestion, gas, and bloating
Full-Strength Pancreatic Enzymes For Humans Healthy Digestion: Lactose-free pancreatin includes protease, lipase enzymes, and amylase enzymes to support digestion and nutrient absorption from protein, fats, and carbohydrates
Clean Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure whats on the label is in the bottle.
Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide

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Why We Love It

Premium Digestive Enzyme Supplement: Supports gut health, digestion, and bowel regularity with one easy-to-swallow capsule taken with meals. Helps support relief from occasional indigestion, gas, and bloating
Full-Strength Pancreatic Enzymes For Humans Healthy Digestion: Lactose-free pancreatin includes protease, lipase enzymes, and amylase enzymes to support digestion and nutrient absorption from protein, fats, and carbohydrates
Clean Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure whats on the label is in the bottle.
Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide

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9.5

Excellent

Designs for Health

Designs for Health Pancreatic Enzymes Complex - Digestive Enzymes + Bromelain Supplement - Support Digestion + Gut Health - Delayed Release Capsule with Pancreatic Enzyme, Ox Bile (90 Capsules)

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Main Highlights

Pancreatic Enzymes & Ox Bile - These pancreatic enzymes are nearly bioidentical to human enzymes and support protein, carbohydrate, and fat digestion. PaleoZyme also includes bromelain to promote protein digestion and ox bile to aid the emulsification of fats.*
Paleo Compliant - Free of grain, legume, and dairy-sourced ingredients, making it ideal for those with sensitivities to these common foods/food groups and those who prefer to maintain a strict Paleo diet.*
Delayed Release - Enteric coating protects the enzymes from stomach acid. This helps preserve their activity for the first section of small intestine, where pancreatic enzymes are intended to function.*
Higher Standards. Better Results - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Gluten-Free Non-GMO.
Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**

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Main Highlights

Pancreatic Enzymes & Ox Bile - These pancreatic enzymes are nearly bioidentical to human enzymes and support protein, carbohydrate, and fat digestion. PaleoZyme also includes bromelain to promote protein digestion and ox bile to aid the emulsification of fats.*
Paleo Compliant - Free of grain, legume, and dairy-sourced ingredients, making it ideal for those with sensitivities to these common foods/food groups and those who prefer to maintain a strict Paleo diet.*
Delayed Release - Enteric coating protects the enzymes from stomach acid. This helps preserve their activity for the first section of small intestine, where pancreatic enzymes are intended to function.*
Higher Standards. Better Results - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Gluten-Free Non-GMO.
Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**

9.5

Excellent

Vital Nutrients

Vital Nutrients Pancreatic Enzymes 1000mg (Full Strength) - Pancreatin Digestion Supplement with Protease, Amylase & Lipase - Digestive Enzymes - Gluten, Dairy, and Soy Free - 180 Capsules

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Main Highlights

Premium Digestive Enzyme Supplement: Supports gut health, digestion, and bowel regularity with one easy-to-swallow capsule taken with meals. Helps support relief from occasional indigestion, gas, and bloating
Full-Strength Pancreatic Enzymes For Humans Healthy Digestion: Lactose-free pancreatin includes protease, lipase enzymes, and amylase enzymes to support digestion and nutrient absorption from protein, fats, and carbohydrates
Clean Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure whats on the label is in the bottle.
Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide

Check Price

Main Highlights

Premium Digestive Enzyme Supplement: Supports gut health, digestion, and bowel regularity with one easy-to-swallow capsule taken with meals. Helps support relief from occasional indigestion, gas, and bloating
Full-Strength Pancreatic Enzymes For Humans Healthy Digestion: Lactose-free pancreatin includes protease, lipase enzymes, and amylase enzymes to support digestion and nutrient absorption from protein, fats, and carbohydrates
Clean Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure whats on the label is in the bottle.
Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide

9.2

Excellent

NOW Foods

NOW Foods Supplements, Pancreatin 2000 with naturally occurring Protease (Protein Digesting), Amylase (Carbohydrate Digesting), and Lipase (Fat Digesting) Enzymes, 250 Capsules

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Main Highlights

DIGESTIVE SUPPORT*: Pancreatin has naturally occurring protease (protein digesting), amylase (carbohydrate digesting), and lipase (fat digesting) enzymes
ASSISTS PROTEIN, FAT, AND CARBOHYDRATE DIGESTION*: Pancreatin is a preparation of porcine pancreatic enzymes
CERTIFICATIONS/CLASSIFICATIONS: Keto Friendly, Soy Free, Nut Free, Made without Gluten, Dairy Free, Egg Free
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

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Main Highlights

DIGESTIVE SUPPORT*: Pancreatin has naturally occurring protease (protein digesting), amylase (carbohydrate digesting), and lipase (fat digesting) enzymes
ASSISTS PROTEIN, FAT, AND CARBOHYDRATE DIGESTION*: Pancreatin is a preparation of porcine pancreatic enzymes
CERTIFICATIONS/CLASSIFICATIONS: Keto Friendly, Soy Free, Nut Free, Made without Gluten, Dairy Free, Egg Free
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

9.0

Excellent

Pure Encapsulations

Pure Encapsulations Pancreatic Enzyme Formula - Digestive Enzymes for Digestion - Strengthens Gut Health* - Targeted Delivery Capsules - Gluten Free & Non-GMO - 60 Capsules

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Main Highlights

Digestive Enzyme Blend for Gut Health: Contains amylase enzyme, lipase enzyme, and protease enzyme supplement to support natural digestion*
Targeted Delivery Capsules: Acid-resistant capsules ensure enzymes for digestionincluding our protease, amylase, and lipasereach the G.I. tract*
Concentrated Pancreatin: Each capsule provides 500 mg of pancreatin for digestive function support, strengthening gut health and aiding digestion*
Suggested Use: As a dietary supplement, take 1 digestive enzymes capsule, 3 times daily, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

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Main Highlights

Digestive Enzyme Blend for Gut Health: Contains amylase enzyme, lipase enzyme, and protease enzyme supplement to support natural digestion*
Targeted Delivery Capsules: Acid-resistant capsules ensure enzymes for digestionincluding our protease, amylase, and lipasereach the G.I. tract*
Concentrated Pancreatin: Each capsule provides 500 mg of pancreatin for digestive function support, strengthening gut health and aiding digestion*
Suggested Use: As a dietary supplement, take 1 digestive enzymes capsule, 3 times daily, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

8.8

Very Good

NOW Foods

NOW Supplements, Pancreatin 10X 200 mg with naturally occurring Protease (Protein Digesting), Amylase (Carbohydrate Digesting), and Lipase (Fat Digesting) Enzymes, 100 Capsules

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Main Highlights

DIGESTIVE SUPPORT*: Pancreatin has naturally occurring protease (protein digesting), amylase (carbohydrate digesting), and lipase (fat digesting) enzymes
ASSISTS PROTEIN, FAT, AND CARBOHYDRATE DIGESTION*: Pancreatin is a preparation of porcine pancreatic enzymes
CERTIFICATIONS/CLASSIFICATIONS: Keto Friendly, Soy Free, Nut Free, Made without Gluten, Dairy Free, Egg Free
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

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Main Highlights

DIGESTIVE SUPPORT*: Pancreatin has naturally occurring protease (protein digesting), amylase (carbohydrate digesting), and lipase (fat digesting) enzymes
ASSISTS PROTEIN, FAT, AND CARBOHYDRATE DIGESTION*: Pancreatin is a preparation of porcine pancreatic enzymes
CERTIFICATIONS/CLASSIFICATIONS: Keto Friendly, Soy Free, Nut Free, Made without Gluten, Dairy Free, Egg Free
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Packaged in the USA by a family owned and operated company since 1968

8.6

Very Good

NOW Foods

NOW Foods Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain,180 Capsules

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Main Highlights

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Founded in 1968 by Elwood Richard, NOW is one of the largest independent, family- and employee-owned manufacturers of natural products

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Main Highlights

SUPPORTS HEALTHY DIGESTION*: NOW Super Enzymes is a comprehensive blend of enzymes that supports healthy digestion.* Take one capsule with a meal
BREAKS DOWN FATS, CARBS, AND PROTEINS*/OPTIMIZES NUTRIENT AVAILABILITY*: Formulated with bromelain, ox bile, pancreatin and papain, Super Enzymes helps to optimize the breakdown of fats, carbohydrates and protein*
CERTIFICATIONS/CLASSIFICATIONS: Soy Free, Made without Gluten, Keto Friendly
GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation)
Founded in 1968 by Elwood Richard, NOW is one of the largest independent, family- and employee-owned manufacturers of natural products

8.3

Very Good

Pure Encapsulations

Pure Encapsulations Pancreatic Enzyme Formula - Digestive Enzymes for Digestion - Strengthens Gut Health* - Targeted Delivery Capsules - Gluten Free & Non-GMO - 180 Capsules

Free Shipping

Main Highlights

Digestive Enzyme Blend for Gut Health: Contains amylase enzyme, lipase enzyme, and protease enzyme supplement to support natural digestion*
Targeted Delivery Capsules: Acid-resistant capsules ensure enzymes for digestionincluding our protease, amylase, and lipasereach the G.I. tract*
Concentrated Pancreatin: Each capsule provides 500 mg of pancreatin for digestive function support, strengthening gut health and aiding digestion*
Suggested Use: As a dietary supplement, take 1 digestive enzymes capsule, 3 times daily, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

Check Price

Main Highlights

Digestive Enzyme Blend for Gut Health: Contains amylase enzyme, lipase enzyme, and protease enzyme supplement to support natural digestion*
Targeted Delivery Capsules: Acid-resistant capsules ensure enzymes for digestionincluding our protease, amylase, and lipasereach the G.I. tract*
Concentrated Pancreatin: Each capsule provides 500 mg of pancreatin for digestive function support, strengthening gut health and aiding digestion*
Suggested Use: As a dietary supplement, take 1 digestive enzymes capsule, 3 times daily, with each meal, or as directed by a health professional
Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs

8.1

Very Good

THORNE

THORNE - Pancreatic Enzymes (Formerly Dipan-9) - Pancreatic Enzymes for Digestive Support and Nutrient Absorption* - 180 Capsules - 90 Servings

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Main Highlights

Pancreatic Enzymes: Lipase, protease, and amylase support the digestion of fats, proteins, carbohydrates*
Absorption: Promotes the absorption of nutrients, especially fats*
Pancreatin: The highest purity and potency pancreatin available
Undiluted: Not diluted with lactose or any other excipients
Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

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Main Highlights

Pancreatic Enzymes: Lipase, protease, and amylase support the digestion of fats, proteins, carbohydrates*
Absorption: Promotes the absorption of nutrients, especially fats*
Pancreatin: The highest purity and potency pancreatin available
Undiluted: Not diluted with lactose or any other excipients
Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

8.1

Very Good

Boulder Bio

Boulder Bio Digestive Enzymes | 40,000 USP Lipase - Prescription Strength Pancreatic Enzyme Replacement Formula for Fat Digestion, Gut Health & Nutrient Absorption - Fermented, Vegan, High Potency

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Main Highlights

Prescription Strength, Single-Source Digestive Enzyme Nutraceutical. Higher potency, higher purity, no prescription required.
Unmatched Purity: BoulderBio's proprietary, cutting edge microbatch microbial manufacturing does not use any toxic solvents and yields enzymes that do not require the chemical additives porcine-based products require to function.
Honest Pricing: More enzyme activity per dollar. 10x the digestive power of leading brands but not 10x the price. We dont dilute our products for profit
Independently Owned Small Business: Researcher owned, research backed, and results proven. Only single-source ingredients, always made locally in the USA.
Seven Decades of Expertise, One Formulation: 50+ years of physician expertise from the world authority on pancreatic health, plus 20 years of academic & clinical research from her son united in one tried-and-true, patent-pending formulation
Small Batch: Crafted in limited runs to ensure uncompromising quality. There is a current limit of 3 bottles per order while we increase production to meet demand

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Main Highlights

Prescription Strength, Single-Source Digestive Enzyme Nutraceutical. Higher potency, higher purity, no prescription required.
Unmatched Purity: BoulderBio's proprietary, cutting edge microbatch microbial manufacturing does not use any toxic solvents and yields enzymes that do not require the chemical additives porcine-based products require to function.
Honest Pricing: More enzyme activity per dollar. 10x the digestive power of leading brands but not 10x the price. We dont dilute our products for profit
Independently Owned Small Business: Researcher owned, research backed, and results proven. Only single-source ingredients, always made locally in the USA.
Seven Decades of Expertise, One Formulation: 50+ years of physician expertise from the world authority on pancreatic health, plus 20 years of academic & clinical research from her son united in one tried-and-true, patent-pending formulation
Small Batch: Crafted in limited runs to ensure uncompromising quality. There is a current limit of 3 bottles per order while we increase production to meet demand

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