Updated:March, 2026

10 Best Best Over The Counter Constipation Relief of 2026

Best Choice

9.9

Outstanding

Prunelax

Prunelax Ciruelax Maximum Relief Laxative Tablets with Natural Senna for Occasional Constipation, Senna Extract, Vegan & Gluten-Free, Gentle Overnight Relief - 100ct

Free Shipping

Why We Love It

Overnight Relief for Occasional Constipation: Fast-acting tablets ensure gentle relief by morning. Feel the difference within 8-12 hours.*
Made with Natural Senna: Each serving contains 250mg of Senna Leaf Extracts, Prunelax Maximum Relief tablets are 66% stronger than Regular Strength Prunelax. Promoting safe, effective, and gentle relief.*
Find Comfort with Ease: Maintain control over occasional constipation and cater to your bodys needs effortlessly. Simply take 2 tablets before bedtime for optimal relief.
Inclusive & Transparent Health: Vegan, gluten-free, and made without artificial additivesour tablets are safe for diverse dietary needs.
Predictable Relief: Prunelax offers gentle & predictable overnight relief, helping you unwind and ensuring a comfortable night's sleep.

Check Price

Why We Love It

Overnight Relief for Occasional Constipation: Fast-acting tablets ensure gentle relief by morning. Feel the difference within 8-12 hours.*
Made with Natural Senna: Each serving contains 250mg of Senna Leaf Extracts, Prunelax Maximum Relief tablets are 66% stronger than Regular Strength Prunelax. Promoting safe, effective, and gentle relief.*
Find Comfort with Ease: Maintain control over occasional constipation and cater to your bodys needs effortlessly. Simply take 2 tablets before bedtime for optimal relief.
Inclusive & Transparent Health: Vegan, gluten-free, and made without artificial additivesour tablets are safe for diverse dietary needs.
Predictable Relief: Prunelax offers gentle & predictable overnight relief, helping you unwind and ensuring a comfortable night's sleep.

How We Find the Top Picks

We use smart data tools to review thousands of products and stores, analyzing ratings, reviews, and popularity trends to highlight what truly matters to shoppers like you.

Our experts then refine the results, blending AI insights with real user experiences to deliver accurate, up-to-date rankings that help you choose with confidence.

9.5

Excellent

Prunelax

Prunelax Ciruelax Maximum Relief Laxative Tablets with Natural Senna for Occasional Constipation, Senna Extract, Vegan & Gluten-Free, Gentle Overnight Relief - 24ct

Free Shipping

Main Highlights

Overnight Relief for Occasional Constipation: Fast-acting tablets ensure gentle relief by morning. Feel the difference within 8-12 hours.*
Made with Natural Senna: Each serving contains 250mg of Senna Leaf Extracts, Prunelax Maximum Relief tablets are 66% stronger than Regular Strength Prunelax. Promoting safe, effective, and gentle relief.*
Find Comfort with Ease: Maintain control over occasional constipation and cater to your bodys needs effortlessly. Simply take 2 tablets before bedtime for optimal relief.
Inclusive & Transparent Health: Vegan, gluten-free, and made without artificial additivesour tablets are safe for diverse dietary needs.
Predictable Relief: Prunelax offers gentle & predictable overnight relief, helping you unwind and ensuring a comfortable night's sleep.

Check Price

Main Highlights

Overnight Relief for Occasional Constipation: Fast-acting tablets ensure gentle relief by morning. Feel the difference within 8-12 hours.*
Made with Natural Senna: Each serving contains 250mg of Senna Leaf Extracts, Prunelax Maximum Relief tablets are 66% stronger than Regular Strength Prunelax. Promoting safe, effective, and gentle relief.*
Find Comfort with Ease: Maintain control over occasional constipation and cater to your bodys needs effortlessly. Simply take 2 tablets before bedtime for optimal relief.
Inclusive & Transparent Health: Vegan, gluten-free, and made without artificial additivesour tablets are safe for diverse dietary needs.
Predictable Relief: Prunelax offers gentle & predictable overnight relief, helping you unwind and ensuring a comfortable night's sleep.

9.5

Excellent

GenCare

GenCare - Senna-S Natural Vegetable Laxative Plus Stool Softener Dual Action (200 Tablets) Value Pack | Gentle Dependable Overnight Relief of Occasional Constipation Generic for Senokot-S

Free Shipping

Main Highlights

NATURAL & DEPENDABLE - Enjoy faster, gentler overnight relief from constipation, bloating, upset stomach and irregularity. Take preferably at bedtime or as directed by a doctor, a single dose generally causes bowel movement within 6 to 12 hours.
DUAL ACTION RELIEF - The all natural vegetable laxative sennosides helps empty your bowels and docusate sodium helps soften hard stools for easier passing and greater comfort. These 2 ingredients work together to allow for an easier and more comfortable bowel movement.
EASY TO USE - Each easy to swallow oral tablet is recommended before bed. Avoid inconvenient and painful suppositories and unpleasant tasting liquids. See the recommended use chart for adults and child dosages. Consult a doctor for children under 2 years old.
FAMILY SIZE SAVINGS - Always keep gentle all natural relief on hand with the GenCare 200 tablet value pack. Save money with the same active ingredients as Senokot-S at a fraction of the price. Keep your home's medicine cabinet stocked year round.

Check Price

Main Highlights

NATURAL & DEPENDABLE - Enjoy faster, gentler overnight relief from constipation, bloating, upset stomach and irregularity. Take preferably at bedtime or as directed by a doctor, a single dose generally causes bowel movement within 6 to 12 hours.
DUAL ACTION RELIEF - The all natural vegetable laxative sennosides helps empty your bowels and docusate sodium helps soften hard stools for easier passing and greater comfort. These 2 ingredients work together to allow for an easier and more comfortable bowel movement.
EASY TO USE - Each easy to swallow oral tablet is recommended before bed. Avoid inconvenient and painful suppositories and unpleasant tasting liquids. See the recommended use chart for adults and child dosages. Consult a doctor for children under 2 years old.
FAMILY SIZE SAVINGS - Always keep gentle all natural relief on hand with the GenCare 200 tablet value pack. Save money with the same active ingredients as Senokot-S at a fraction of the price. Keep your home's medicine cabinet stocked year round.

9.2

Excellent

TRP THE RELIEF PRODUCTS

The Relief Products Constipation Relief - 100% Natural Active Ingredients - Fast Dissolving Tablets - 50ct

Free Shipping

Main Highlights

Constipation relief provides temporary relief from the symptoms of constipation, such as difficult elimination, dry or hard stools, cramping, ineffectual urging and evacuation, gas, bloating, or hemorrhoids
Natural active ingredients
Constipation relief is safe and gentle to use, with no side effects, interactions with other medications, or contraindications
Made in the USA

Check Price

Main Highlights

Constipation relief provides temporary relief from the symptoms of constipation, such as difficult elimination, dry or hard stools, cramping, ineffectual urging and evacuation, gas, bloating, or hemorrhoids
Natural active ingredients
Constipation relief is safe and gentle to use, with no side effects, interactions with other medications, or contraindications
Made in the USA

9.0

Excellent

HealthA2Z

HealthA2Z Laxative Bisacodyl 5mg | 100 Counts | Gentle and Fast Overnight Relief for Constipation

Free Shipping

Main Highlights

The active ingredient is Bisacodyl 5mg which is a stimulant laxative.
Reliable overnight relief from constipation: HealthA2Z Laxative provides reliable and predictable overnight relief by gently stimulating the intestines to encourage a morning bowel movement.
Works in 6-12 hours: HealthA2Z Laxative works by gently stimulating the bowel muscles to provide reliable relief of constipation in 6-12 hours.

Check Price

Main Highlights

The active ingredient is Bisacodyl 5mg which is a stimulant laxative.
Reliable overnight relief from constipation: HealthA2Z Laxative provides reliable and predictable overnight relief by gently stimulating the intestines to encourage a morning bowel movement.
Works in 6-12 hours: HealthA2Z Laxative works by gently stimulating the bowel muscles to provide reliable relief of constipation in 6-12 hours.

8.8

Very Good

HealthA2Z

HealthA2Z Laxative Bisacodyl 5mg | 250 Counts | Gentle and Fast Overnight Relief for Constipation

Free Shipping

Main Highlights

The active ingredient is Bisacodyl 5mg which is a stimulant laxative.
Reliable overnight relief from constipation: HealthA2Z Laxative provides reliable and predictable overnight relief by gently stimulating the intestines to encourage a morning bowel movement.
Works in 6-12 hours: HealthA2Z Laxative works by gently stimulating the bowel muscles to provide reliable relief of constipation in 6-12 hours.

Check Price

Main Highlights

The active ingredient is Bisacodyl 5mg which is a stimulant laxative.
Reliable overnight relief from constipation: HealthA2Z Laxative provides reliable and predictable overnight relief by gently stimulating the intestines to encourage a morning bowel movement.
Works in 6-12 hours: HealthA2Z Laxative works by gently stimulating the bowel muscles to provide reliable relief of constipation in 6-12 hours.

8.6

Very Good

Phillips'

Phillips’ Milk of Magnesia Liquid Laxative, Wild Cherry Flavor, Stimulant Free, Cramp Free Relief of Occasional Constipation*, Effective in 30 minutes - 6 hours, #1 Milk of Magnesia Brand, 26 oz

Free Shipping

Main Highlights

GENTLE OVERNIGHT CONSTIPATION RELIEF: Phillips Milk of Magnesia Wild Cherry Flavor liquid laxative is a saline laxative that provides dependable, overnight relief of occasional constipation* so you can get back to regular
STIMULANT AND CRAMP FREE: Provides gentle, overnight relief of occasional constipation* with no harsh stimulants
STARTS WORKING IN ½ HOUR TO 6 HOURS: Generally produces a bowel movement in under 6 hours. It may be taken once a day, preferably at bedtime, in divided doses, or as directed by a doctor. Drink 8oz of liquid with each dose
#1 MILK OF MAGNESIA BRAND: Phillips has been a trusted name in digestive health for over 150 years
DEPENDABLE CONSTIPATION RELIEF FOR ADULTS AND CHILDREN AGES 6+: Recommended dose for adults and children 12 years and older: 30mL - 60mL. Children 6-11 year: 15mL - 30mL. Children under 6 years: ask a doctor

Check Price

Main Highlights

GENTLE OVERNIGHT CONSTIPATION RELIEF: Phillips Milk of Magnesia Wild Cherry Flavor liquid laxative is a saline laxative that provides dependable, overnight relief of occasional constipation* so you can get back to regular
STIMULANT AND CRAMP FREE: Provides gentle, overnight relief of occasional constipation* with no harsh stimulants
STARTS WORKING IN ½ HOUR TO 6 HOURS: Generally produces a bowel movement in under 6 hours. It may be taken once a day, preferably at bedtime, in divided doses, or as directed by a doctor. Drink 8oz of liquid with each dose
#1 MILK OF MAGNESIA BRAND: Phillips has been a trusted name in digestive health for over 150 years
DEPENDABLE CONSTIPATION RELIEF FOR ADULTS AND CHILDREN AGES 6+: Recommended dose for adults and children 12 years and older: 30mL - 60mL. Children 6-11 year: 15mL - 30mL. Children under 6 years: ask a doctor

8.3

Very Good

GenCare

GenCare Senna Laxative 600 Tablets Senna 8.6mg Tablets with Natural Sennosides | Laxatives for Constipation, Bloating, Gas & Irregularity Relief. Safe & Effective | Generic for Senokot

Free Shipping

Main Highlights

BULK SAVINGS BOTTLE - Always keep yourself and your family prepared with our vegetable based stool softeners that come in an ultra convenient 600 bulk savings family container. Adults and children (see directions) can get comforting intestinal and bowel relief from our convenient easy swallow tablets.
ALL NATURAL REGULARITY - Avoid harsh chemicals and strange colon cleanse concoctions and instead opt for our vegetable based laxatives for constipation sennosides from the Senna medicinal plant. These tablets will help relieve constipation and stimulate bowel movement so that you can pass your stool more comfortably.
GAS & BLOATING RELIEF - Constipation symptoms may include visible and uncomfortable bloating, flatulence or gas that gets trapped in your body. GenCare Senna tablets can help reduce these symptoms by naturally causing movement of your colon and intestines to naturally eliminate gasses and waste.
TAKE BEFORE BED - For best results take laxatives for constipation fast acting tablets as directed in the evening before bedtime as the sennosides take 6-12 hours to reach full effect. You'll wake up with less gas, bloating and likely to experience a comfortable bowel movement in the morning with reliability and regularity.
100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 600 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of constipation relief customers...Click Add-to-Cart Today!

Check Price

Main Highlights

BULK SAVINGS BOTTLE - Always keep yourself and your family prepared with our vegetable based stool softeners that come in an ultra convenient 600 bulk savings family container. Adults and children (see directions) can get comforting intestinal and bowel relief from our convenient easy swallow tablets.
ALL NATURAL REGULARITY - Avoid harsh chemicals and strange colon cleanse concoctions and instead opt for our vegetable based laxatives for constipation sennosides from the Senna medicinal plant. These tablets will help relieve constipation and stimulate bowel movement so that you can pass your stool more comfortably.
GAS & BLOATING RELIEF - Constipation symptoms may include visible and uncomfortable bloating, flatulence or gas that gets trapped in your body. GenCare Senna tablets can help reduce these symptoms by naturally causing movement of your colon and intestines to naturally eliminate gasses and waste.
TAKE BEFORE BED - For best results take laxatives for constipation fast acting tablets as directed in the evening before bedtime as the sennosides take 6-12 hours to reach full effect. You'll wake up with less gas, bloating and likely to experience a comfortable bowel movement in the morning with reliability and regularity.
100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 600 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of constipation relief customers...Click Add-to-Cart Today!

8.1

Very Good

Senokot

Senokot-S Dual Action 60 Tablets, Natural Vegetable Laxative Ingredient Plus Stool Softener Tablets, Gentle Dependable Overnight Relief of Occasional constipation White

Free Shipping

Main Highlights

GENTLE, DEPENDABLE, OVERNIGHT RELIEF. Senokot-S uses a standardized senna concentrate, a natural vegetable laxative with docusate sodium, a stool softener, to provide gentle relief. For predictable, comfortable relief of occasional constipation.
GENTLE, EFFECTIVE RELIEF. Senokot-S Dual Action combines the proven strength of Senokot with the gentleness of a stool softener. For occasional constipation, Senokot-S Tablets provide gentle, effective overnight relief you can count on.
EASES DISCOMFORT OF OCCASIONAL CONSTIPATION. Senokot-S Dual Action Tablets provide gentle relief and ease the discomfort associated with hard, dry stools, using both the natural vegetable laxative ingredient senna as well as a stool softener.
HELPS RELIEVE OCCASIONAL CONSTIPATION. Senokot-S Dual Action combines a natural vegetable laxative ingredient with a stool softener. Can be used in children ages 2 plus.
DEPENDABLE RELIEF. Like all Senokot Laxative products, Senokot-S Dual Action tablets are produced from the natural vegetable laxative ingredient senna, providing dependable, overnight relief from occasional constipation.

Check Price

Main Highlights

GENTLE, DEPENDABLE, OVERNIGHT RELIEF. Senokot-S uses a standardized senna concentrate, a natural vegetable laxative with docusate sodium, a stool softener, to provide gentle relief. For predictable, comfortable relief of occasional constipation.
GENTLE, EFFECTIVE RELIEF. Senokot-S Dual Action combines the proven strength of Senokot with the gentleness of a stool softener. For occasional constipation, Senokot-S Tablets provide gentle, effective overnight relief you can count on.
EASES DISCOMFORT OF OCCASIONAL CONSTIPATION. Senokot-S Dual Action Tablets provide gentle relief and ease the discomfort associated with hard, dry stools, using both the natural vegetable laxative ingredient senna as well as a stool softener.
HELPS RELIEVE OCCASIONAL CONSTIPATION. Senokot-S Dual Action combines a natural vegetable laxative ingredient with a stool softener. Can be used in children ages 2 plus.
DEPENDABLE RELIEF. Like all Senokot Laxative products, Senokot-S Dual Action tablets are produced from the natural vegetable laxative ingredient senna, providing dependable, overnight relief from occasional constipation.

8.1

Very Good

P Puregen Labs

Puregen Labs Bisacodyl 5mg Tablet | 200 Count | Stimulant Laxative, Gentle and Fast Overnight Relief for Constipation

Free Shipping

Main Highlights

OPTIMAL EFFECT: Our Laxative Bisacodyl 5mg tablets have an effective laxative formula that can help provide gentle relief from occasional constipation.
EFECTIVE FORMULA: These tablets contain a powerful active ingredient, bisacodyl 5 mg, known for its amazing effect on constipation by helping the intestine move so you can pass stool more easily, it also has softening effect on the stool.
PREDICTABLE RELIEF: You can say goodbye to the uncomfortable feeling caused by constipation or irregularity. These tablets will provide gentle, effective and predictable overnight relief.
FOR ORAL USE ONLY: Puregen Labs Bisacodyl 5mg tablets are for the oral use only. Please consult your primary care doctor before using the product.
QUALITY YOU CAN TRUST: Our formula is made in a facility following strict GMP guidelines to ensure safety and quality.

Check Price

Main Highlights

OPTIMAL EFFECT: Our Laxative Bisacodyl 5mg tablets have an effective laxative formula that can help provide gentle relief from occasional constipation.
EFECTIVE FORMULA: These tablets contain a powerful active ingredient, bisacodyl 5 mg, known for its amazing effect on constipation by helping the intestine move so you can pass stool more easily, it also has softening effect on the stool.
PREDICTABLE RELIEF: You can say goodbye to the uncomfortable feeling caused by constipation or irregularity. These tablets will provide gentle, effective and predictable overnight relief.
FOR ORAL USE ONLY: Puregen Labs Bisacodyl 5mg tablets are for the oral use only. Please consult your primary care doctor before using the product.
QUALITY YOU CAN TRUST: Our formula is made in a facility following strict GMP guidelines to ensure safety and quality.

Discover top deals and categories on Amazon Check Deals