Updated:April, 2026

10 Best Best Nighttime Cough Medicine of 2026

Best Choice

9.9

Outstanding

Robitussin

Robitussin Maximum Strength Nighttime Cough DM Max, Adult Formula, Berry Flavor - 8 Fl Oz Bottle

Free Shipping

Why We Love It

One 8 fl oz bottle of Robitussin Maximum Strength Nighttime Cough DM Max, Adult Formula, Berry Flavor
Provides cough relief as well as relief from symptoms due to hay fever or other upper respiratory allergies
Liquid cough suppressant that is easy and quick to take
Robitussin Nighttime DM Cough Medicine provides soothing relief in a great-tasting, berry flavor
Nighttime cold medicine formulated to control your impulse to cough to help you sleep
Take 20 mL by mouth every six hours, preferably before bed
Robitussin recently conducted a First of Its Kind RealWorld Evidence study showing that Robitussin Nighttime DM Max helps provide fast, powerful cough relief to help you fall asleep fast and stay asleep starting from Night 1.
HSA and FSA eligible product

Check Price

Why We Love It

One 8 fl oz bottle of Robitussin Maximum Strength Nighttime Cough DM Max, Adult Formula, Berry Flavor
Provides cough relief as well as relief from symptoms due to hay fever or other upper respiratory allergies
Liquid cough suppressant that is easy and quick to take
Robitussin Nighttime DM Cough Medicine provides soothing relief in a great-tasting, berry flavor
Nighttime cold medicine formulated to control your impulse to cough to help you sleep
Take 20 mL by mouth every six hours, preferably before bed
Robitussin recently conducted a First of Its Kind RealWorld Evidence study showing that Robitussin Nighttime DM Max helps provide fast, powerful cough relief to help you fall asleep fast and stay asleep starting from Night 1.
HSA and FSA eligible product

How We Find the Top Picks

We use smart data tools to review thousands of products and stores, analyzing ratings, reviews, and popularity trends to highlight what truly matters to shoppers like you.

Our experts then refine the results, blending AI insights with real user experiences to deliver accurate, up-to-date rankings that help you choose with confidence.

9.5

Excellent

Mucinex

Mucinex Nightshift Sinus, Cold And Flu Cough Medicine For Adults, Powerful Nighttime Sinus Medicine For Sinus Relief, Sore Throat Relief, Cough Suppressant & Nasal Decongestant For Adults, 6 Fl Oz

Free Shipping

Main Highlights

COUGH MEDICINE ADULTS: Tackle nighttime coughing woes head-on with Mucinex Nightshift Sinus; This liquid formula helps to relieve your worst nighttime sinus and nasal congestion symptoms, so you can wake up ready to conquer the day
COLD MEDICINE: Find relief from fever, headache, minor aches, sore throat, cough, sneezing, and runny nose with Mucinex Nightshift Sinusa powerful liquid formula designed to tackle nighttime sinus symptoms effectively
NIGHTTIME COLD AND FLU SYMPTOM RELIEF: Mucinex Nightshift Sinus helps to reduce fever, relieve headache, minor aches and pains, sore throat, coughing, sneezing, runny nose for a better morning
SINUS RELIEF + SORE THROAT RELIEF: Mucinex Nightshift is a powerful sinus medicine that provides sinus relief & sore throat relief; Contains Acetaminophen which helps reduce fever & relieves minor aches & pains including sore throat pain
MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCl - Nasal Decongestant; Triprolidine HCl Antihistamine
USAGE: Use as directed; For ages 12+ years

Check Price

Main Highlights

COUGH MEDICINE ADULTS: Tackle nighttime coughing woes head-on with Mucinex Nightshift Sinus; This liquid formula helps to relieve your worst nighttime sinus and nasal congestion symptoms, so you can wake up ready to conquer the day
COLD MEDICINE: Find relief from fever, headache, minor aches, sore throat, cough, sneezing, and runny nose with Mucinex Nightshift Sinusa powerful liquid formula designed to tackle nighttime sinus symptoms effectively
NIGHTTIME COLD AND FLU SYMPTOM RELIEF: Mucinex Nightshift Sinus helps to reduce fever, relieve headache, minor aches and pains, sore throat, coughing, sneezing, runny nose for a better morning
SINUS RELIEF + SORE THROAT RELIEF: Mucinex Nightshift is a powerful sinus medicine that provides sinus relief & sore throat relief; Contains Acetaminophen which helps reduce fever & relieves minor aches & pains including sore throat pain
MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCl - Nasal Decongestant; Triprolidine HCl Antihistamine
USAGE: Use as directed; For ages 12+ years

9.5

Excellent

Robitussin

Robitussin DM Max Cough Plus Chest Congestion and Robitussin Maximum Strength Nighttime Cough DM, Adult Formulas - 2 x 8 Fl Oz Bottles

Free Shipping

Main Highlights

One 8 fl oz bottle of Robitussin Adult Maximum Strength Cough Plus Chest Congestion DM Max and One 8 fl oz bottle of Maximum Strength Nighttime Cough DM
Robitussin Cough Plus Chest Congestion daytime cold medicine delivers temporary relief from cough and chest congestion
Robitussin nighttime cold medicine for adults contains an antihistamine for relief of runny nose and sneezing and a cough suppressant to control your cough so you can sleep
Liquid cough suppressant for adults that's easy to measure and administer
Raspberry for daytime and Wildberry for nighttime cough medicine
Pack includes day and night cough relief medication for adults
Formulated for adults and children ages 12 and over

Check Price

Main Highlights

One 8 fl oz bottle of Robitussin Adult Maximum Strength Cough Plus Chest Congestion DM Max and One 8 fl oz bottle of Maximum Strength Nighttime Cough DM
Robitussin Cough Plus Chest Congestion daytime cold medicine delivers temporary relief from cough and chest congestion
Robitussin nighttime cold medicine for adults contains an antihistamine for relief of runny nose and sneezing and a cough suppressant to control your cough so you can sleep
Liquid cough suppressant for adults that's easy to measure and administer
Raspberry for daytime and Wildberry for nighttime cough medicine
Pack includes day and night cough relief medication for adults
Formulated for adults and children ages 12 and over

9.2

Excellent

Amazon Basic Care

Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine, Multi-Symptom Relief, for Adults and Children 12 Years and Older, Mixed Berry Flavor, 12 fl oz (Pack of 1)

Free Shipping

Main Highlights

ACTIVE INGREDIENTS: Contains acetaminophen 650 mg, dextromethorphan HBr 20 mg, doxylamine succinate 12.5 mg, and phenylephrine HCl 10 mg, which compares to the active ingredients in Vicks NyQuil Severe
MAXIMUM STRENGTH: Amazon Basic Care Nighttime Severe Cold and Flu Relief provides maximum strength relief of headache, fever, sore throat, minor aches and pains, sinus congestion and pressure, sneezing, runny nose and cough
NIGHTTIME RELIEF: Provides cold care through the night; this cold and flu medicine relieves cold and flu symptoms so you can rest; does not contain pseudoephedrine
EFFECTIVE: Each dose contains a pain reliever, fever reducer, cough suppressant, antihistamine and nasal decongestant
MIXED BERRY FLAVOR LIQUID: This liquid cold and flu medicine comes in tasty mixed berry flavor and provides multi-symptom relief; alcohol free, sugar free and gluten free

Check Price

Main Highlights

ACTIVE INGREDIENTS: Contains acetaminophen 650 mg, dextromethorphan HBr 20 mg, doxylamine succinate 12.5 mg, and phenylephrine HCl 10 mg, which compares to the active ingredients in Vicks NyQuil Severe
MAXIMUM STRENGTH: Amazon Basic Care Nighttime Severe Cold and Flu Relief provides maximum strength relief of headache, fever, sore throat, minor aches and pains, sinus congestion and pressure, sneezing, runny nose and cough
NIGHTTIME RELIEF: Provides cold care through the night; this cold and flu medicine relieves cold and flu symptoms so you can rest; does not contain pseudoephedrine
EFFECTIVE: Each dose contains a pain reliever, fever reducer, cough suppressant, antihistamine and nasal decongestant
MIXED BERRY FLAVOR LIQUID: This liquid cold and flu medicine comes in tasty mixed berry flavor and provides multi-symptom relief; alcohol free, sugar free and gluten free

9.0

Excellent

Theraflu

Theraflu Severe Cold and Cough Nighttime and Daytime Cough and Cold Medicine, Berry Flavor - 8.3 Fl Oz Syrup x 2

Free Shipping

Main Highlights

One 8.3 fl oz bottle of Theraflu Severe Cold and Cough Daytime Medicine, Berry Flavor and one 8.3 fl oz bottle of Theraflu Severe Cold and Cough Nighttime Medicine, berry flavored nighttime and daytime cough and cold medicine
Delivers powerful pain relief and headache relief, along with relief from sore throat, fever and cough
Daytime and nighttime cough syrup formulations provide a unique warming sensation and delivers fast cough, cold and sore throat relief
Both syrups come in a delicious berry flavor
Nighttime adult cough syrup and sore throat medicine also contains an antihistamine to relieve runny nose and sneezing
Both cold and cough syrups contain acetaminophen 650 mg; daytime syrup also contains dextromethorphan HBr and nighttime contains Diphenhydramine HCI
Adults and children 12 years and older: take 30mL of either daytime or nighttime cold medicine every four hours as needed for cold and cough symptom relief
The nighttime syrup formula contains Acetaminophen 650 mg and Diphenhydramine HCl 25 mg
HSA and FSA eligible product

Check Price

Main Highlights

One 8.3 fl oz bottle of Theraflu Severe Cold and Cough Daytime Medicine, Berry Flavor and one 8.3 fl oz bottle of Theraflu Severe Cold and Cough Nighttime Medicine, berry flavored nighttime and daytime cough and cold medicine
Delivers powerful pain relief and headache relief, along with relief from sore throat, fever and cough
Daytime and nighttime cough syrup formulations provide a unique warming sensation and delivers fast cough, cold and sore throat relief
Both syrups come in a delicious berry flavor
Nighttime adult cough syrup and sore throat medicine also contains an antihistamine to relieve runny nose and sneezing
Both cold and cough syrups contain acetaminophen 650 mg; daytime syrup also contains dextromethorphan HBr and nighttime contains Diphenhydramine HCI
Adults and children 12 years and older: take 30mL of either daytime or nighttime cold medicine every four hours as needed for cold and cough symptom relief
The nighttime syrup formula contains Acetaminophen 650 mg and Diphenhydramine HCl 25 mg
HSA and FSA eligible product

8.8

Very Good

Safetussin

Safetussin PM Night Time Cold and Cough Medicine for Adults, 8 oz, Cough Relief Syrup

Free Shipping

Main Highlights

NIGHTTIME COUGH RELIEF: Safetussin PM is a pharmacist-developed cough medicine that is safe for diabetic patients & high blood pressure because its free of sugar, alcohol, dye, decongestants, & gluten
COUGH RELIEF TO HELP YOU REST: Pharmacist-recommended Safetussin PM cold medicine adults trust for up to 8 hours of cough relief, helping you get the rest you need when battling the common cold
THE CLEAR CHOICE: Safetussin PM Cough Syrup with dextromethorphan helps temporarily relieve cold symptoms such as cough, runny nose, & sneezing without unwanted additives or ingredients found in other cold medicines. Essential for every medicine cabinet
SAFE & EFFECTIVE: Safetussin runny nose relief for adults formulated with dextromethorphan & doxylamine succinate to treat nighttime cough in adults with high blood pressure or diabetes; safe cough relief without decongestants or sugar
SELF-CARE SOLUTIONS: At Kramer Laboratories we focus on consumer needs to help provide innovative solutions to everyday healthcare problems. Try our full line of Safetussin cough and cold medicine for adults, cough syrups for adults

Check Price

Main Highlights

NIGHTTIME COUGH RELIEF: Safetussin PM is a pharmacist-developed cough medicine that is safe for diabetic patients & high blood pressure because its free of sugar, alcohol, dye, decongestants, & gluten
COUGH RELIEF TO HELP YOU REST: Pharmacist-recommended Safetussin PM cold medicine adults trust for up to 8 hours of cough relief, helping you get the rest you need when battling the common cold
THE CLEAR CHOICE: Safetussin PM Cough Syrup with dextromethorphan helps temporarily relieve cold symptoms such as cough, runny nose, & sneezing without unwanted additives or ingredients found in other cold medicines. Essential for every medicine cabinet
SAFE & EFFECTIVE: Safetussin runny nose relief for adults formulated with dextromethorphan & doxylamine succinate to treat nighttime cough in adults with high blood pressure or diabetes; safe cough relief without decongestants or sugar
SELF-CARE SOLUTIONS: At Kramer Laboratories we focus on consumer needs to help provide innovative solutions to everyday healthcare problems. Try our full line of Safetussin cough and cold medicine for adults, cough syrups for adults

8.6

Very Good

Amazon Basic Care

Amazon Basic Care Nighttime Severe Cold and Flu Syrup, Max Strength Liquid Medicine for Cough, Sore Throat, Nasal Congestion, Pain Reliever, Fever Reducer, Original, 12 fl oz

Free Shipping

Main Highlights

ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks NyQuil Severe Cold and Flu, acetaminophen 650 mg, dextromethorphan HBr 20 mg, doxylamine succinate 12.5 mg and phenylephrine HCl 10 mg
MAXIMUM STRENGTH RELIEF: Each dose includes a pain reliever/fever reducer, cough suppressant, antihistamine and nasal decongestant so you can rest; this medicine also contains ten percent alcohol
FOR NIGHT TIME USE: Amazon Basic Care Night Time Severe Cold and Flu Relief soothes your severe symptoms to help you sleep
MULTI-SYMPTOM RELIEF: Temporarily relieves common cold and flu symptoms: fever, minor aches and pains, sore throat, coughing, sneezing, runny nose and sinus pressure
SOOTHES COLD AND FLU SYMPTOMS: Promotes nasal and/or sinus drainage and temporarily restores freer breathing through the nose; this medicine is sugar free and gluten free; for ages 12 and older

Check Price

Main Highlights

ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks NyQuil Severe Cold and Flu, acetaminophen 650 mg, dextromethorphan HBr 20 mg, doxylamine succinate 12.5 mg and phenylephrine HCl 10 mg
MAXIMUM STRENGTH RELIEF: Each dose includes a pain reliever/fever reducer, cough suppressant, antihistamine and nasal decongestant so you can rest; this medicine also contains ten percent alcohol
FOR NIGHT TIME USE: Amazon Basic Care Night Time Severe Cold and Flu Relief soothes your severe symptoms to help you sleep
MULTI-SYMPTOM RELIEF: Temporarily relieves common cold and flu symptoms: fever, minor aches and pains, sore throat, coughing, sneezing, runny nose and sinus pressure
SOOTHES COLD AND FLU SYMPTOMS: Promotes nasal and/or sinus drainage and temporarily restores freer breathing through the nose; this medicine is sugar free and gluten free; for ages 12 and older

8.3

Very Good

Amazon Basic Care

Amazon Basic Care Nighttime Cold and Flu Medicine, Maximum Strength, Original Flavor Liquid, Multi-Symptom Relief for Cough, Sore Throat, Fever, 12 fl oz (1-Pack)

Free Shipping

Main Highlights

ACTIVE INGREDIENTS: Compare to NyQuil Cold and Flu active ingredients: acetaminophen (pain reliever and fever reducer), dextromethorphan HBr (cough suppressant), and doxylamine succinate (antihistamine)
MAXIMUM STRENGTH: Amazon Basic Care Nighttime Cold and Flu Relief provides maximum strength, multi-symptom relief to help you sleep
POWERFUL NIGHTTIME RELIEF: Each dose relieves minor aches and pains, fever, sore throat, sneezing, runny nose and cough for up to 6 hours so you can rest
LIQUID MEDICINE: Amazon Basic Care Nighttime Cold and Flu Relief is a liquid medicine in original flavor; get the relief you need in a liquid
AGES 12 AND OLDER: This cold and flu medicine is safe for adults and children ages 12 and over; gluten free

Check Price

Main Highlights

ACTIVE INGREDIENTS: Compare to NyQuil Cold and Flu active ingredients: acetaminophen (pain reliever and fever reducer), dextromethorphan HBr (cough suppressant), and doxylamine succinate (antihistamine)
MAXIMUM STRENGTH: Amazon Basic Care Nighttime Cold and Flu Relief provides maximum strength, multi-symptom relief to help you sleep
POWERFUL NIGHTTIME RELIEF: Each dose relieves minor aches and pains, fever, sore throat, sneezing, runny nose and cough for up to 6 hours so you can rest
LIQUID MEDICINE: Amazon Basic Care Nighttime Cold and Flu Relief is a liquid medicine in original flavor; get the relief you need in a liquid
AGES 12 AND OLDER: This cold and flu medicine is safe for adults and children ages 12 and over; gluten free

8.1

Very Good

Robitussin

Robitussin Maximum Strength Cough + Chest Congestion DM And Maximum Strength Nighttime Cough DM, Cough Medicine For Adults, Berry Flavor - 4 Fl Oz Bottles (Pack of 2)

Free Shipping

Main Highlights

Two 4 fluid ounce bottles of Robitussin Maximum Strength Cough + Chest Congestion DM and Maximum Strength Nighttime Cough DM, Cough Medicine for Adults, Berry Flavor
Robitussin Cough + Chest Congestion daytime cold medicine delivers temporary relief from cough and chest congestion
Robitussin nighttime cold medicine for adults contains an antihistamine for relief of runny nose and sneezing and a cough suppressant to control your cough so you can sleep
Liquid cough suppressant for adults that's easy to measure and administer
Berry-flavored adult cough medicine

Check Price

Main Highlights

Two 4 fluid ounce bottles of Robitussin Maximum Strength Cough + Chest Congestion DM and Maximum Strength Nighttime Cough DM, Cough Medicine for Adults, Berry Flavor
Robitussin Cough + Chest Congestion daytime cold medicine delivers temporary relief from cough and chest congestion
Robitussin nighttime cold medicine for adults contains an antihistamine for relief of runny nose and sneezing and a cough suppressant to control your cough so you can sleep
Liquid cough suppressant for adults that's easy to measure and administer
Berry-flavored adult cough medicine

8.1

Very Good

Tylenol

Tylenol Extra Strength Severe Cough + Sore Throat Nighttime Liquid Cold Medicine, Multi-Symptom Cold Relief, Acetaminophen Pain Reliever, Dextromethorphan HBr, Doxylamine Succinate, 8 Oz.

Free Shipping

Main Highlights

8-fluid ounce bottle of Tylenol Extra Strength Severe Cough + Sore Throat Nighttime Liquid Cold Medicine with acetaminophen for multi-symptom cold & flu, cough & sore throat relief
The extra strength nighttime relief liquid is formulated to temporarily reduce fevers & relieve common cold or flu symptoms such as minor body aches & pains, headache, sore throat & cough
Each dose of Tylenol Extra Strength Nighttime liquid contains 1,000 mg of acetaminophen, a pain reliever & fever reducer, 30 mg of dextromethorphan HBr, a cough suppressant, as well as 12.5 mg of doxylamine succinate, an antihistamine
Take 30 mL of Tylenol Extra Strength liquid in the dosing cup provided every 6 hours while symptoms last. Do not take more than 90 mL in 24 hours, unless directed by a doctor
From the #1 doctor recommended pain relief brand, Tylenol Extra Strength Severe Cough + Sore Throat Nighttime liquid cold medicine can be used by adults & children 12 years & older for cough & sore throat relief at night

Check Price

Main Highlights

8-fluid ounce bottle of Tylenol Extra Strength Severe Cough + Sore Throat Nighttime Liquid Cold Medicine with acetaminophen for multi-symptom cold & flu, cough & sore throat relief
The extra strength nighttime relief liquid is formulated to temporarily reduce fevers & relieve common cold or flu symptoms such as minor body aches & pains, headache, sore throat & cough
Each dose of Tylenol Extra Strength Nighttime liquid contains 1,000 mg of acetaminophen, a pain reliever & fever reducer, 30 mg of dextromethorphan HBr, a cough suppressant, as well as 12.5 mg of doxylamine succinate, an antihistamine
Take 30 mL of Tylenol Extra Strength liquid in the dosing cup provided every 6 hours while symptoms last. Do not take more than 90 mL in 24 hours, unless directed by a doctor
From the #1 doctor recommended pain relief brand, Tylenol Extra Strength Severe Cough + Sore Throat Nighttime liquid cold medicine can be used by adults & children 12 years & older for cough & sore throat relief at night

Discover top deals and categories on Amazon Check Deals