Updated:May, 2026

10 Best B12 Methylcobalamin And Methyl Folate of 2026

Best Choice

9.9

Outstanding

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

Why We Love It

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

Check Price

Why We Love It

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

How We Find the Top Picks

We use smart data tools to review thousands of products and stores, analyzing ratings, reviews, and popularity trends to highlight what truly matters to shoppers like you.

Our experts then refine the results, blending AI insights with real user experiences to deliver accurate, up-to-date rankings that help you choose with confidence.

9.5

Excellent

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

Check Price

Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

9.5

Excellent

Triquetra Health

Organic Methyl Folate 1000 mcg + Methyl B12 Cofactor (300 Servings) – Metabolically Active 5-MTHF Form, Organic Berry Flavor, Liquid Sublingual Form – Mood, Cognition, Methylation, Pregnancy (1oz)

Main Highlights

BIOLOGICALLY ACTIVE FORM OF FOLATE (1 mg or 1000 mcg) : L-Methylfolate is the biological active form of Folate. It immediately absorbs into bloodstream and requires no processing by the body. The 1 mg dose is ideal to address daily Folate nutritional needs.*
ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.*
ENHANCED SUBLINGUAL ABSORPTION, CHERRY FLAVOR: The liquid sublingual form of L-methylfolate immediately absorbs directly into the bloodstream with higher overall absorption.*
SUPPORTS HEALTHY METHYLATION: The L Methyl Folate form of Folate is essential for healthy methylation especially for those with MTHFR gene.*
PREGNANCY, BRAIN, MOOD, ENERGY SUPPORT, CARDIOVASCULAR: 1 mg of Methylfolate supports healthy baby development during pregnancy. It is also essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.* Methylfolate also supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.*

Check Price

Main Highlights

BIOLOGICALLY ACTIVE FORM OF FOLATE (1 mg or 1000 mcg) : L-Methylfolate is the biological active form of Folate. It immediately absorbs into bloodstream and requires no processing by the body. The 1 mg dose is ideal to address daily Folate nutritional needs.*
ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.*
ENHANCED SUBLINGUAL ABSORPTION, CHERRY FLAVOR: The liquid sublingual form of L-methylfolate immediately absorbs directly into the bloodstream with higher overall absorption.*
SUPPORTS HEALTHY METHYLATION: The L Methyl Folate form of Folate is essential for healthy methylation especially for those with MTHFR gene.*
PREGNANCY, BRAIN, MOOD, ENERGY SUPPORT, CARDIOVASCULAR: 1 mg of Methylfolate supports healthy baby development during pregnancy. It is also essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.* Methylfolate also supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide production.*

9.2

Excellent

Triquetra Health

L Methyl Folate 1000 mcg Plus Methyl B12 Cofactor – Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Highly Bioavailable Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 1000 mcg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

Check Price

Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 1000 mcg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

9.0

Excellent

Sports Research

Sports Research® Methyl Folate + B12-1000 mcg L-Methylfolate & 2000 mcg Methylcobalamin for Cellular Energy Support - Vegan B12 w/Coconut MCT Oil - Non-GMO, Gluten Free - 90 Veggie Softgels

Main Highlights

METHYLATED B COMPLEX SUPPORT* L-METHYLFOLATE + METHYL B12: Delivers 1000 mcg DFE L-Methylfolate (5-MTHF) and 2000 mcg Vitamin B12 as Methylcobalamin, the bioactive forms of folate and B12 designed for optimal absorption and bioavailability.*
CELLULAR ENERGY*: Vitamin B12 supports cellular energy production, acting as a coenzyme, breaking down carbohydrates, proteins and fats for daily cellular energy.*
ACTIVE FOLATE 1000 MCG (5-MTHF): Provides L-Methylfolate, the active form of folic acid, to support methylation throughout the body.
PLANTGELS WITH COCONUT MCT OIL: Formulated with coconut-derived MCT oil to support absorption in easy-to-swallow veggie softgels.*
NON-GMO & GLUTEN FREE SUPPLEMENT: Certified Non-GMO and free from gluten, dairy, and soy. Manufactured in cGMP-compliant facilities and third-party tested for quality and purity.

Check Price

Main Highlights

METHYLATED B COMPLEX SUPPORT* L-METHYLFOLATE + METHYL B12: Delivers 1000 mcg DFE L-Methylfolate (5-MTHF) and 2000 mcg Vitamin B12 as Methylcobalamin, the bioactive forms of folate and B12 designed for optimal absorption and bioavailability.*
CELLULAR ENERGY*: Vitamin B12 supports cellular energy production, acting as a coenzyme, breaking down carbohydrates, proteins and fats for daily cellular energy.*
ACTIVE FOLATE 1000 MCG (5-MTHF): Provides L-Methylfolate, the active form of folic acid, to support methylation throughout the body.
PLANTGELS WITH COCONUT MCT OIL: Formulated with coconut-derived MCT oil to support absorption in easy-to-swallow veggie softgels.*
NON-GMO & GLUTEN FREE SUPPLEMENT: Certified Non-GMO and free from gluten, dairy, and soy. Manufactured in cGMP-compliant facilities and third-party tested for quality and purity.

8.8

Very Good

Jarrow Formulas

Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 & Vitamin B12 Supplement, Supports Cellular Energy Production, Healthy Brain Function & Metabolism, 100 Chewable Tablets, 100 Servings

Main Highlights

Full-Body Benefits: This Jarrow Formulas methylated B12 and B9 supplement combines the active forms of these vitamins to support cellular energy production, healthy brain function, DNA and neurotransmitter synthesis, and amino acid metabolism(1)
Homocysteine Metabolism: Methyl B-12 and methyl folate in this B12 and folate supplement facilitate metabolism of homocysteine into methionine, while P5P supports amino acid metabolism, including pathways involved in cysteine production (1)
Chewable Tablet: Each naturally flavored chewable tablet delivers 2.5 mg vitamin B6, 680 mcg DFE folate, and methyl B12 1000mcg; our B9 & B12 vegan formula has no wheat, gluten, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame
Superior Nutrition and Formulation: The goal of Jarrow B12 is to promote optimal health with effective, affordable and superior formulation of vitamin B12 supplements; our customers can be assured purity and value

Check Price

Main Highlights

Full-Body Benefits: This Jarrow Formulas methylated B12 and B9 supplement combines the active forms of these vitamins to support cellular energy production, healthy brain function, DNA and neurotransmitter synthesis, and amino acid metabolism(1)
Homocysteine Metabolism: Methyl B-12 and methyl folate in this B12 and folate supplement facilitate metabolism of homocysteine into methionine, while P5P supports amino acid metabolism, including pathways involved in cysteine production (1)
Chewable Tablet: Each naturally flavored chewable tablet delivers 2.5 mg vitamin B6, 680 mcg DFE folate, and methyl B12 1000mcg; our B9 & B12 vegan formula has no wheat, gluten, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame
Superior Nutrition and Formulation: The goal of Jarrow B12 is to promote optimal health with effective, affordable and superior formulation of vitamin B12 supplements; our customers can be assured purity and value

8.6

Very Good

Nutricost

Nutricost Methylated Vitamin B12 + Folate Supplement (2,000 mcg) 120 Capsules - 1,000 mcg of Vitamin B12 + 1,000 mcg of Methyl Folate, Gluten-Free, 60 Servings

Main Highlights

Methylated Formula Each serving provides 1,000mcg of methylated Vitamin B12 (methylcobalamin) and 1,000mcg of methyl folate (Vitamin B9)
Generous Supply 120 easy-to-swallow capsules per bottle
Added Support Includes 30mg of calcium per serving
Quality Choice Gluten-free and made with high standards
Manufactured in an NSF Certified, GMP Compliant, FDA Registered Facility

Check Price

Main Highlights

Methylated Formula Each serving provides 1,000mcg of methylated Vitamin B12 (methylcobalamin) and 1,000mcg of methyl folate (Vitamin B9)
Generous Supply 120 easy-to-swallow capsules per bottle
Added Support Includes 30mg of calcium per serving
Quality Choice Gluten-free and made with high standards
Manufactured in an NSF Certified, GMP Compliant, FDA Registered Facility

8.3

Very Good

Pure Encapsulations

Pure Encapsulations B12 Folate - Energy Supplement to Support Nerves, Energy Metabolism & Cognitive Support* - with Vitamin B Folate as Metafolin - 60 Capsules

Main Highlights

Premium Folate Supplement: Vitamin B12 and folate help convert carbohydrates into energy and break down proteins in the body; provides metabolism support*
Nervous System Support: Vitamin B12 (methylcobalamin) and folate (L-5-MTHF) support the nervous system, and function as hair, skin, and liver aids.*
Cognitive Support: Folate is essential for fetal neural development; B12 is an important nutrient for memory and cognitive support*
Supports Gut Health: Support G.I. tract thanks to the active form of the B12 vitamin, methylcobalamin; also a liver support supplement*
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

Check Price

Main Highlights

Premium Folate Supplement: Vitamin B12 and folate help convert carbohydrates into energy and break down proteins in the body; provides metabolism support*
Nervous System Support: Vitamin B12 (methylcobalamin) and folate (L-5-MTHF) support the nervous system, and function as hair, skin, and liver aids.*
Cognitive Support: Folate is essential for fetal neural development; B12 is an important nutrient for memory and cognitive support*
Supports Gut Health: Support G.I. tract thanks to the active form of the B12 vitamin, methylcobalamin; also a liver support supplement*
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

8.1

Very Good

Jarrow Formulas

Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 and Vitamin B12 Supplement, Supports Cellular Energy Production, Healthy Brain Function & Metabolism, 60 Chewable Tablets, 60 Servings

Main Highlights

Bioactive B Vitamins: Jarrow Methyl B-12 & Methylfolate provides methylcobalamin (methyl B-12) and methyl folate, which are the biologically active forms of B9 & B12 vitamins, plus pyridoxal-5-phosphate (P5P), the coenzyme form of vitamin B6
Full-Body Benefits: This Jarrow Formulas methylated B12 and B9 supplement combines the active forms of these vitamins to support cellular energy production, healthy brain function, DNA and neurotransmitter synthesis, and amino acid metabolism(1)
Homocysteine Metabolism: Methyl B-12 and methyl folate in this B12 and folate supplement facilitate metabolism of homocysteine into methionine, while P5P supports amino acid metabolism, including pathways involved in cysteine production (1)
Convenient Chewable Tablet: Each naturally fruit-flavored chewable tablet delivers 2.5 mg vitamin B6, 1360 mcg DFE folate, and methyl B12 5000mcg; our B9 & B12 vegan formula has no wheat, gluten, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame
Superior Nutrition and Formulation: The goal of Jarrow B12 is to promote optimal health with high-quality, effective, affordable and superior formulation of vitamin B12 supplements; our customers can be assured purity and value

Check Price

Main Highlights

Bioactive B Vitamins: Jarrow Methyl B-12 & Methylfolate provides methylcobalamin (methyl B-12) and methyl folate, which are the biologically active forms of B9 & B12 vitamins, plus pyridoxal-5-phosphate (P5P), the coenzyme form of vitamin B6
Full-Body Benefits: This Jarrow Formulas methylated B12 and B9 supplement combines the active forms of these vitamins to support cellular energy production, healthy brain function, DNA and neurotransmitter synthesis, and amino acid metabolism(1)
Homocysteine Metabolism: Methyl B-12 and methyl folate in this B12 and folate supplement facilitate metabolism of homocysteine into methionine, while P5P supports amino acid metabolism, including pathways involved in cysteine production (1)
Convenient Chewable Tablet: Each naturally fruit-flavored chewable tablet delivers 2.5 mg vitamin B6, 1360 mcg DFE folate, and methyl B12 5000mcg; our B9 & B12 vegan formula has no wheat, gluten, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts or sesame
Superior Nutrition and Formulation: The goal of Jarrow B12 is to promote optimal health with high-quality, effective, affordable and superior formulation of vitamin B12 supplements; our customers can be assured purity and value

8.1

Very Good

Seeking Health

Seeking Health Methyl B12 with L-Methylfolate - MTHFR Support Supplement - Methylation Support Supplement - Lozenges to Support Brain Health & Energy - 60 Lozenges

Main Highlights

Energy Support Supplement: This supplement contains 1,360 mcg of methylated folate in its bioavailable form of L-methylfolate
Supplement with Methylcobalamin and Adenosylcobalamin: The supplement lozenges contain 1,000 mcg of vitamin B12; these lozenges support focus and brain health
Easy-to-Take Lozenge: This methylation support supplement comes in an easy-to-take lozenge form; can be broken into smaller pieces for lower dosage if needed
Allergen-Friendly Brain Support: This active vitamin B12 supplement is free of GMOs, gluten, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame, and soy
Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust

Check Price

Main Highlights

Energy Support Supplement: This supplement contains 1,360 mcg of methylated folate in its bioavailable form of L-methylfolate
Supplement with Methylcobalamin and Adenosylcobalamin: The supplement lozenges contain 1,000 mcg of vitamin B12; these lozenges support focus and brain health
Easy-to-Take Lozenge: This methylation support supplement comes in an easy-to-take lozenge form; can be broken into smaller pieces for lower dosage if needed
Allergen-Friendly Brain Support: This active vitamin B12 supplement is free of GMOs, gluten, eggs, fish, shellfish, tree nuts, peanuts, wheat, sesame, and soy
Optimizing Healthy Living: From research to packaging, Seeking Health prioritizes quality and safety at every step of the production process to provide health support you can trust

Discover top deals and categories on Amazon Check Deals